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| Clinical and biochemical basic research of the qi and yin deficiency syndrome of coronary heart disease stable angina |
| Hits 1678 Download times 2047 Received:October 15, 2018 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2019.01.06 |
| Key Words
coronary heart disease stable angina pectoris;qi and yin deficiency syndrome;clinical biochemistry;multi-centers;finesse |
| Author Name | Affiliation | E-mail | | XU Yilan | Tianjin University of Traditional Chinese Medicine, Tianjin 301617 | | | GAO Shan | Tianjin University of Traditional Chinese Medicine, Tianjin 301617 | | | DENG Bing | Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China | | | MAO Meijiao | Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China | | | DU Tinghai | The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 136300, China | | | LI Bin | The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 136300, China | | | YANG Baoping | Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730699, China | | | YU Yan | Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730699, China | | | ZHANG Hong | Tianjin Nankai Hospital, Tianjin 300100, China | | | ZHANG Shishu | Tianjin Nankai Hospital, Tianjin 300100, China | | | MAO Jingyuan | The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | WANG Xianliang | The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | XU Qiang | The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300150, China | | | ZHANG Lei | Tianjin Wuqing Hospital of Traditional Chinese Medicine, Tianjin 301700, China | | | SONG Guangming | Tianjin Wuqing Hospital of Traditional Chinese Medicine, Tianjin 301700, China | | | TIAN Li | Tianjin Wuqing Hospital of Traditional Chinese Medicine, Tianjin 301700, China | | | WANG Li | Tianjin Second People Hospital, Tianjin 300192, China | | | YAN Dandan | Tianjin University of Traditional Chinese Medicine, Tianjin 301617 | | | LI Lin | Tianjin University of Traditional Chinese Medicine, Tianjin 301617 | | | GAO Shuming | Tianjin University of Traditional Chinese Medicine, Tianjin 301617 | | | PAN Ye | Tianjin University of Traditional Chinese Medicine, Tianjin 301617 | | | CAI Xuemeng | Tianjin University of Traditional Chinese Medicine, Tianjin 301617 | | | WANG Shuo | Tianjin University of Traditional Chinese Medicine, Tianjin 301617 | | | LI Xiaofeng | Tianjin University of Traditional Chinese Medicine, Tianjin 301617 | | | AI Le | Tianjin Zhongxin Pharmaceutical Group Limited by Share Ltd. Lerentang Pharmaceutical Factory, Tianjin 300112, China | | | HU Jingqing | Institue of Basic Theory of Traditional Chinese Medicine, China Academy of Chinese Medicine Science, Beijing 100070, China | | | BIAN Yuhong | Tianjin University of Traditional Chinese Medicine, Tianjin 301617 | bianyuhong_2012@163.com | | YU Chunquan | Tianjin University of Traditional Chinese Medicine, Tianjin 301617 | ycq-4@163.com |
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| Abstract
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| [Objective] To explore the qi and yin deficiency syndrome of coronary heart disease by clinical biochemical basis through comparing the strict screening of coronary heart disease stable angina pectoris by clinical and biochemical indexes of patients and healthy people with the multicenter, small sample and fineness clinical research.[Methods] From the seven clinical research centers, 82 cases were selected to the observation. With 3 cases deletion, 79 cases were eventually into the subjects, including 39 cases of qi and yin deficiency syndrome, which were treated with traditional Chinese medicine on the basis of the routine treatment of Western medicine, and 40 healthy people were not involved in the treatment. Endothelial cell injury was detected, lipid metabolism, adhesion molecules and inflammatory mediators, metalloproteinases, homocysteine and blood coagulation function 7 class 28 indicators, were detected in patients with coronary heart disease (CHD) level 0, 8, 12 weeks, healthy people group testing at 0 week.[Results] The correlation between qi and yin deficiency syndrome of CHD and ApoB, LDL-C, AngⅡ was larger. After treatment of Tongmai Yangxin Pills, the level of AngⅠ, ET and sCD40L level were decreased (P<0.05). Overall levels of inflammatory cytokines tended to decrease.[Conclusion] The biochemical basis of Tongmai Yangxin Pills for the regulation of stable angina pectoris with CHD qi and yin deficiency syndrome is related to endothelial injury, lipid metabolism and inflammatory factors, which can provide reference for the next study. |
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