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| Value of combined measurement of heart-type fatty acid-binding protein and calprotectin in diagnosis of ST segment elevation myocardial infarction |
| Hits 1710 Download times 1348 Received:August 13, 2018 |
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| DOI
10.11656/j.issn.1672-1519.2019.01.09 |
| Key Words
ST segment elevation myocardial infarction;heart-type fatty acid-binding protein;calprotectin;diagnosis |
| Author Name | Affiliation | E-mail | | ZHU Jiaping | Department of Medicine, Xiangyang Central Hospital Affiliated Hospital of Hubei University of Arts and Science, Xiangyang 441021, China | | | YAN Nengbing | Department of Medicine, Xiangyang Central Hospital Affiliated Hospital of Hubei University of Arts and Science, Xiangyang 441021, China | ynb1000@163.com |
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| Abstract
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| [Objective] To observe the value of combined measurement of heart-type fatty acid-binding protein (H-FABP) and calprotectin (S100A/B) in diagnosis of ST segment elevation myocardial infarction (STEMI).[Methods] A total of 41 patients with STEMI (case group) and 38 patients with non-cardiogenic chest pain (control group) were collected as study individuals. ELISA kit was used to measure the levels of serum H-FABP and S100A/B. The clinical value of combined measurement of H-FABP and S100A/B in diagnosis of STEMI was assessed.[Results] The levels of serum H-FABP and S100A/B in case group were significantly increased compared with control group (P<0.05). In the case group, serum H-FABP level was positively associated with S100A/B level (P<0.05). In the diagnosis of STEMI, H-FABP alone, S100A/B alone, and H-FABP/S100A/B combination had sensitivities of 81.05%, 76.08% and 80.67%, specificities of 70.25%, 74.61% and 89.27%, and areas under the ROC curves of 0.81, 0.77 and 0.89.[Conclusion] Patients with STEMI have significant increases in H-FABP and S100A/B levels, and there is a correlation among them. Combined measurement of H-FABP and S100A/B can increase the value of the diagnosis of STEMI. |
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