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| Efficacy and safety of resolving hard lump for non-small cell lung cancer: A Meta-analysis |
| Hits 1525 Download times 1242 Received:August 30, 2018 |
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| DOI
10.11656/j.issn.1672-1519.2019.01.12 |
| Key Words
resolving hard lump;non-small cell lung cancer;Meta-analysis;rystematic review;randomized controlled trial |
| Author Name | Affiliation | E-mail | | ZHANG Lishuang | Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | YANG Fengwen | Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LI Xuemei | Baokang Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | lxmtcm@126.com | | ZHANG Junhua | Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | JIN Xinyao | Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHANG Mingyan | Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | FENG Rui | Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHAO Hongjie | Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | JI Zhaochen | Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | |
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| Abstract
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| [Objective] This systematic review aims to systematically evaluate the efficacy and safety of resolving hard lump on the treatment of non-small cell lung cancer (NSCLC).[Methods] We searched CNKI datebases, WanFang, SinoMed, PubMed, Embase, The Cochrane Library from the inception to October 16th 2017, to collect randomized controlled trials (RCTs) of the resolving hard lump in treating NSCLC. Two reviewers independently screened literature, extracted date and assessed the methodological quality of included studies. Then, statistical analysis was performed by using Stata12.0 and WinBUGS1.4.3 sofware.[Resluts] A total of 40 RCTs nvolved 3201 patients were finally included,in which 5 different dosage forms and 34 interventions. There mainly were decoction, pill, capsule, mixture, and injection. The result of direct Meta-analysis showed that compared with the simple chemotherapy group, resolving hard lump prescription combined with chemotherapeutic drugs could significantly improve the clinical efficacy, improve the quality of life of patients, prolong progression free survival and decrease adverse reactions of chemotherapeutic drugs.[Conclusion] Resolving hard lump prescription combined with chemotherapeutics were more effective than the simple chemotherapy group in terms of clinical efficacy, the quality of life, and decrease adverse reactions. Due to the low quality of included studies,more high quality RCTs are needed to verify the above conclusion. |
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