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| Study on characteristics of TCM syndrome in Parkinson's disease with defecation disorder |
| Hits 1536 Download times 967 Received:October 09, 2018 |
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| DOI
10.11656/j.issn.1672-1519.2019.02.10 |
| Key Words
Parkinson disease;defecation disorder;syndrome characteristics;correlation |
| Author Name | Affiliation | E-mail | | ZHANG Tianqing | The 3rd Department of Encephalopathy, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China | | | SHI Jing | The 3rd Department of Encephalopathy, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China | | | LI Ting | The 3rd Department of Encephalopathy, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China | | | QIN Bin | Department of Neurology, Beijing hospital, Beijing 100730, China | | | FAN Dongsheng | Department of Neurology, Peking University Third hospital, Beijing 100191, China | | | LIU Na | Department of Neurology, Peking University Third hospital, Beijing 100191, China | | | LI Yumeng | The 3rd Department of Encephalopathy, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China | | | ZHOU Hufang | The 3rd Department of Encephalopathy, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China | | | TIAN Haolin | The 3rd Department of Encephalopathy, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China | | | JI Xianyue | The 3rd Department of Encephalopathy, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China | | | JIA Dongdong | The 3rd Department of Encephalopathy, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China | | | TIAN Jinzhou | The 3rd Department of Encephalopathy, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China | jztian@hotmail.com |
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| Abstract
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| [Objective] To investigate the characteristics of traditional Chinese medicine (TCM) syndromes of Parkinson disease (PD) in defecation disorders and to provide evidence for the treatment of PD defecation disorders in Chinese medicine.[Methods] The 102 patients with PD who were included were classified into PD defecation disorder group (44 cases) and non-defecation disorder group (58 cases) according to the diagnostic criteria of defecation disorder. Patients with two groups were treated with the syndrome score of Parkinson's disease (PD-PES-13). To analyze the features of TCM syndromes of PD defecation disorder and its correlation with TCM syndromes.[Results] In terms of syndrome scores, the scores for myelination were highest in both groups (9.44±5.98) for defecation disorder group and (9.18±5.60) for non-defecation disorder group. After chi-square test, the proportion of spleen-deficiency in PD patients was higher than that of patients without defecation (P<0.01). In patients with PD defecation disorder, there was a positive correlation between declining myelin levels and HOEHN&YAHR (H&Y) scores (P<0.05). And there was a linear relationship (P<0.01) among myelination syndrome, hepatic wind syndrome, and Parkinson's disease rating scale (Unified Parkinson's). The scores of Disease Rating Scale (UPDRS) were correlated (P<0.05 or P<0.01).[Conclusion] PD may be prominent with myeloid degeneration. Spleen deficiency may have effects on PD patients with defecation disorders. The higher the H&Y grade in patients with PD defecation disorder, the higher the marrow reduction certificate. With the increase of UPDRS scores, patients with PD defecation disorder have gradually increased their pith and hepatic wind syndrome. |
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