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| Clinical research on treating acute bronchial asthma of evil heat obstructing lung with Maxing Shigan Decoction combined with conventional therapy |
| Hits 1551 Download times 1418 Received:December 01, 2018 |
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| DOI
10.11656/j.issn.1672-1519.2019.02.13 |
| Key Words
bronchial asthma;acute;evil heat obstructing lung;Maxing Shigan Decoction;conventional therapy;clinical curative effect |
| Author Name | Affiliation | E-mail | | MA Jingwei | Department of Respiratory Medicine, Baoji Hospital of traditional Chinese Medicine, Baoji 712000, China | | | GONG Zhenhua | Department of Respiratory Medicine, Baoji Jintai Hospital, Baoji 721001, China | 695828820@qq.com |
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| Abstract
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| [Objective] In order to evaluate the clinical curative effect by the method of Maxing Shigan Decoction combined with conventional therapy to treat acute bronchial asthma of evil heat obstructing lung syndrome, and explore the mechanism.[Methods] The 188 cases patients of acute bronchial asthma of evil heat obstructing lung syndrome accorded with the inclusion criteria were selected and randomly divided into the experimental group and the control group, each group had 94 patients. With 10 cases lost in the study, the lost rate was 5.32%. A total of 178 patients were completed, including 90 in the experimental group and 88 in the control group. The control group was given conventional Western medicine therapy, the experimental group was given Maxing Shigan Decoction combined with conventional Western medicine therapy, 1 week for a course and 2 courses were treated consecutively of two groups and followed up for 6 months; after 2 courses of treatment, two groups of TCM syndromes effect, asthma symptoms, lung function, exhaled gas-nitric oxide(FeNO) score and the clinical efficacy were observed. After 6 months treatment, expression levels of serum IL-4, IFN-γ and recurrence were observed.[Results] The score of respite, coughing, sputum, chest tightness and wheezing in the two groups was lower than before treatment (P<0.05). After treatment, the TCM syndrome score of the experimental group was lower than that of the control group (P<0.05). After treatment, both the day and night symptoms were lower than before treatment, with significant difference (P<0.05), the experimental group was lower than the control group (P<0.05). The lung function was improved after treatment than before in 2 groups (P<0.05); the experimental group was better than the control group (P<0.05). The FeNO levels of two groups were no significantly reduced (P<0.05), and the FeNO levels of the experimental group was lower than the control group (P<0.05). The total effective rate of the experimental group was 96.7% and 89.8% in the control group, and the difference in the efficiency of the two groups was no statistically significant (χ2=3.363, P>0.05). After 6 months treatment, 2 groups of patients with serum IL-4 expression level decreased significantly (P<0.05), while IFN-γ increased significantly (P<0.05), and the level of IL-4 decreased and the level of IFN-γ increased were better than the control group (P<0.05).[Conclusion] Maxing Shigan Decoction combined with conventional therapy can effectively relieve the clinical symptoms of patients with bronchial asthma, improve respiratory function, reduce FeNO level, satisfactory effect, and patient compliance. |
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