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| Effects of curcumin capsule with methotrexate on bone erosion in rheumatoid arthritis |
| Hits 2062 Download times 1013 Received:November 16, 2018 |
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| DOI
10.11656/j.issn.1672-1519.2019.03.08 |
| Key Words
rheumatoid arthritis;bone erosion;curcumin capsule;RANK/RANKL/OPG system |
| Author Name | Affiliation | E-mail | | LIN Jing | Department of Traditional Chinese Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin 150000, China
Postdoctoral Workstation, Heilongjiang Academy of Traditional Chinese Medicine, Harbin 150000, China | | | YU Huimin | Department of Traditional Chinese Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin 150000, China | | | WANG Tao | Department of Basic Theory of Traditional Chinese Medicine, Heilongjiang University of Traditional Chinese Medicine, Harbin 150000, China | 11076311@qq.com |
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| Abstract
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| [Objective] To observe the effects of curcumin capsule with methotrexate on bone erosion in rheumatoid arthritis.[Methods] Totally 128 inpatients and outpatients of RA were randomly assigned to the treatment group (prescribed curcumin capsule and MTX for 64 cases) and the control group(prescribed with MTX alone for 64 cases),the effect of disease activity score in 28 joints (DAS28),laboratory related indices rheumatoid factor and the levels of OPG and RANKL were observed after 12-week treatment.[Results] After treatment,the levels of DAS28,PLT,TNF-α,RANKL and RANKL/OPG were significantly lower than before treatment (P<0.05),and the control group was higher than treatment group (P<0.05),and the levels of HGB,OPG was significantly increased than before treatment in both groups (P<0.05),and the control group was worse than treatment group (P<0.05).[Conclusion] Curcumin capsule with methotrexate could effectively improve joints and systemic symptoms in RA patients and regulate bone erosion induced by RANK/RANKL/OPG system. |
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