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| Antipruritic effects of essential oil of Cinnamomum camphora leaves |
| Hits 3730 Download times 1125 Received:November 30, 2018 |
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| DOI
10.11656/j.issn.1672-1519.2019.03.23 |
| Key Words
Cinnamomum camphora leaves;essential oil;antipruritic effect |
| Author Name | Affiliation | E-mail | | YANG Jinqiang | Nanjing University of Chinese Medicine, Nanjing 210023, China | | | YANG Nianyun | Nanjing University of Chinese Medicine, Nanjing 210023, China | nianyunyang@163.com |
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| Abstract
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| [Objective] To study the antipruritic effect of essential oil of Cinnamomum camphora leaves and its possible mechanism.[Methods] The model of pruritus induced by 4-aminopyridine in mice and the model of allergic contact dermatitis induced by 2,4-dinitrofluorobenzene in mice were explored. The antipruritic effect of essentia oil of Cinnamomum camphora leaves was investigated.[Results] In 4-aminopyridine pruritus model,compared with the model group the number of licking body in high and low doses of essential oil group was significantly decreased in 10 min (P<0.01). The contents of LTB4 and 5-HT were significantly decreased (P<0.05). However,the essential oil of Cinnamomum camphora leaf had no significant effect on IL-4 (P>0.05). Pathological examination showed a large number of inflammatory cells in the model group. Inflammatory cells were not seen in the high and low doses of essential oil group. The dermis slightly thickened in the low doses of essential oil group. In the 2,4-dinitrofluorobenzene model of allergic contact dermatitis,compared with the model group the contents of LTB4 was significantly decreased (P<0.05). However,the essential oil of Cinnamomum camphora leaves had no significant effect on IL-4 (P>0.05).[Conclusion] Essential oil of Cinnamomum camphora leaves has a significant antipruritic effect. Its mechanism is to reduce the contents of 5-HT and LTB4. |
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