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| Research progress on the effect and mechanism of Qili Qiangxin Capsule in treating chronic heart failure |
| Hits 4901 Download times 4377 Received:January 02, 2019 |
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| DOI
10.11656/j.issn.1672-1519.2019.04.01 |
| Key Words
chronic heart failure;vessel-collateral doctrine;Qili Qiangxin Capsule;the effect and mechanism |
| Author Name | Affiliation | E-mail | | ZHAO Qifei | Graduate School, Hebei Medical University, Shijiazhuang 050017, China
Affiliated Yiling Hospital of Hebei Medical University, Key Disciplines of State Administration of TCM for Collateral Disease, Shijiazhuang 050091, China | | | LI Hongrong | Graduate School, Hebei Medical University, Shijiazhuang 050017, China
Affiliated Yiling Hospital of Hebei Medical University, Key Disciplines of State Administration of TCM for Collateral Disease, Shijiazhuang 050091, China | | | YIN Yujie | Affiliated Yiling Hospital of Hebei Medical University, Key Disciplines of State Administration of TCM for Collateral Disease, Shijiazhuang 050091, China
Hebei Yiling Pharmaceutical Research Institute, Key Laboratory of State Administration of TCM, Shijiazhuang 050035, China | | | CHANG Liping | Hebei Yiling Pharmaceutical Research Institute, Key Laboratory of State Administration of TCM, Shijiazhuang 050035, China
Shijiazhuang Yiling Pharmaceutical Co., Ltd, National Key Laboratory of Collateral Disease Research and Innovative Chinese Medicine, Shijiazhuang 050035, China | | | JIA Zhenhua | Graduate School, Hebei Medical University, Shijiazhuang 050017, China
Affiliated Yiling Hospital of Hebei Medical University, Key Disciplines of State Administration of TCM for Collateral Disease, Shijiazhuang 050091, China
Hebei Yiling Pharmaceutical Research Institute, Key Laboratory of State Administration of TCM, Shijiazhuang 050035, China | jiatcm@163.com |
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| Abstract
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| Chronic heart failure is a key part of cardiovascular continuum. Under the guidance of the theory of vessel-collateral doctrine,the present study proposes therapeutic benefits of Qili Qiangxin Capsules,an innovative Chinese medicine,on chronic heart failure. The studies show that multiple targets of the drug on chronic heart failure,including enhancing myocardial systole,promoting urine excretion,inhibiting excessive activation of the neuroendocrine system,preventing ventricular remodeling by inhibiting inflammatory response,myocardial fibrosis,apoptosis and autophagy,enhancing myocardial energy metabolism,promoting angiogenesis and improving endothelial function. To investigate the effect and mechanism of the drug is beneficial to the treatment of chronic heart failure through multiple targets or signaling pathways. Meanwhile,it provides new insights to further understand other refractory diseases in the cardiovascular continuum,and it also has an important theoretical and practical significance in enhancing prevention and therapeutic effect of traditional Chinese medicine for these diseases. |
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