|
| Systematic review of Fufang Xueshuan Tong combined with calcium dobesilate in treating diabetic retinopaphy |
| Hits 1423 Download times 1082 Received:October 30, 2018 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2019.04.17 |
| Key Words
Fufang Xueshuan Tong;calciumdobesilate;diabetic retinopathy;systematic review;Meta-analysis |
| Author Name | Affiliation | E-mail | | CHEN Bomian | Fourth Clinical Medical College, Guangzhou University of Traditional Chinese Medicine, Shenzhen 518033, China | | | LIU Yuling | Fourth Clinical Medical College, Guangzhou University of Traditional Chinese Medicine, Shenzhen 518033, China | | | WANG Dongcai | Endocrinology Department, Traditional Chinese Medicine Hospital of Shenzhen, Shenzhen 518033, China | 13823713909@163.com | | ZHAO Hengxia | Endocrinology Department, Traditional Chinese Medicine Hospital of Shenzhen, Shenzhen 518033, China | | | LI Huilin | Endocrinology Department, Traditional Chinese Medicine Hospital of Shenzhen, Shenzhen 518033, China | | | ZHANG Xuewen | Shaanxi University of Traditional Chinese Medicine, Xianyang 712000, China | |
|
| Abstract
|
| [Objective] To evaluate the therapeutic effect of Fufang Xueshuan Tong combined with calciumdobesilate in treating diabetic retinopaphy. To design a systematic review of randomized controlled trials.[Methods] Search databases as CNKI,VIP,Wanfang,CBM,PubMed and Cochrane Library (time from build libraries to March 2018) relevant journals and the literature of RCTs of the combination of Fufang Xueshuan Tong and calciumdobesilate in treating diabetic retinopaphy were all enrolled. To evaluate the bias of the literature according to the standard of the Cochrane system evaluation member manual bias risk assessment and extract the data. The meta-analyses were performed with Review Manager 5.3 software.[Results] Thirteen articles were enrolled. The result of Meta-analyses showed that intervention measures could improve the clinical comprehensive effect[OR=5.69,95%CI(3.54,9.14),P<0.000 01],improve fundus situation(vision grayscale values[WMD=-1.00,95%CI(-1.15,-0.86),P<0.000 01],the volume of hemangioma[WMD=-3.43,95%CI(-4.22,-2.64),P<0.000 01],the contact area[WMD=-1.06,95%CI(-1.39,-0.72),P<0.000 01]),increase TCM symptom complex score[WMD=-3.93,95%CI(-4.87,-2.99),P<0.000 01], reduce the whole blood viscosity[WMD=-0.61,95%CI(-1.01,-0.22),P<0.002],reduce recurrence[OR=0.13,95%CI(0.04,0.47),P=0.002]. Besides,four articles indicated that fufangxueshuantong combined with calciumdobesilate could reduce the levels of VEGF,IGF-1 and hs-CRP.[Conclusion] The combination of Fufang Xueshuan Tong and calciumdobesilate would enhance the comprehensive therapeutic effect of diabetic retinopaphy. However,we need more high-quality RCTs to improve the research. |
|
|
|
|
|
|
|
