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| Meta-analysis of Xiaoaiping Injection combined with chemotherapy in the treatment of advanced non-small cell lung cancer |
| Hits 1701 Download times 968 Received:November 18, 2018 |
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| DOI
10.11656/j.issn.1672-1519.2019.05.14 |
| Key Words
Xiaoaiping Injection;non-small cell lung cancer;Meta-analysis |
| Author Name | Affiliation | E-mail | | ZHANG Mengdi | Department of Oncology, First Teaching Hospital of Tianjin University of Chinese Medicine, Tianjin 300381, China
Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | MOU Ruiyu | Department of Oncology, First Teaching Hospital of Tianjin University of Chinese Medicine, Tianjin 300381, China
Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LIU Honggen | Department of Oncology, First Teaching Hospital of Tianjin University of Chinese Medicine, Tianjin 300381, China | | | YANG Peiying | Department of Oncology, First Teaching Hospital of Tianjin University of Chinese Medicine, Tianjin 300381, China | | | WANG Xiaoqun | Department of Oncology, First Teaching Hospital of Tianjin University of Chinese Medicine, Tianjin 300381, China | | | JIA Yingjie | Department of Oncology, First Teaching Hospital of Tianjin University of Chinese Medicine, Tianjin 300381, China | jiayingjie1616@sina.com |
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| Abstract
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| [Objective] This study systematically evaluated the clinical efficacy and adverse reactions of Xiaoaiping Injection combined with chemotherapy in the treatment of advanced non-small cell lung cancer (NSCLC) from the perspective of evidence-based medicine.[Methods] The literatures as of May 2018 were published in the Cochrane Library,PubMed,EMBASE,CNKI,Wanfang data,and VIP. The randomized controlled trial of Xiaoaiping injection combined with chemotherapy in the treatment of non-small cell lung cancer was included. For the included studies,the "The Cochrane Collaboration's tool for assessing risk of bias" was used for literature quality evaluation. Data on study characteristics,methods,and results were extracted,analyzed using RevMan 5.3,and published bias was examined.[Results] A total of 26 articles were included,and a total of 1 783 cases were included. As a result,compared with the chemotherapy alone group,Xiaoaiping Injection combined with chemotherapy can improve the total effective rate of patients (RR=1.30,95% CI[1.16,1.46],P<0.000 01),disease control rate (RR=1.17,95% CI[1.10,1.23],P<0.000 01),quality of life (RR=2.16,95% CI[1.80,2.61],P<0.00001),and reduced the occurrence of adverse reactions.[Conclusion] Xiaoaiping Injection can improve the efficacy of chemotherapy in patients with advanced non-small cell lung cancer,improve the quality of life and reduce adverse reactions. |
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