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| Overview of animal models of gout and hyperuricemia and metabolic pathway analysis |
| Hits 2378 Download times 1876 Received:November 15, 2018 |
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| DOI
10.11656/j.issn.1672-1519.2019.05.23 |
| Key Words
gout;arthragia syndrome;hyperuricemia;animal model;metabolic pathway |
| Author Name | Affiliation | E-mail | | SHI Xuliu | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | QIAO Miao | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WU Mingjiang | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Hongmin | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | DING Liqin | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | QIU Feng | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | fengqiu20070118@163.com |
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| Abstract
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| Arthragia syndrome is a chronic metabolic disease caused by elevated levels of uric acid in the blood due to purine metabolic disturbance that can present in multiple ways,such as hyperuricemia,gouty kidney disease,gouty arthritis and so on. The trend of gout incidence rate shows a recent increase. In order to elucidate the pathogenesis of gout and find out more effective drugs,the establishment and selection of experimental animal models are critical. Based on different methods,experimental animal models of gout and hyperuricemia can be established by sufficient uric acid or its precursor-induced gout model,potassium oxonate-,fungal products-,drug-induced hyperuricemia. The paper systematically summarized the methods of animal models of gout and hyperuricemia. The metabolic pathways of induced model groups can be compared to clinical hyperuricemia patients',by means of metabolomics analysis,which provides references for further researches on metabolic pathways and pathogenesis of gout and hyperuricemia. |
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