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| Effects of the GEE and LMM models in clinical treatments of coronary heart disease by Tongmai Yangxin Pill |
| Hits 1827 Download times 1348 Received:March 05, 2019 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2019.06.02 |
| Key Words
stable angina pectoris of coronary heart disease;linear mixed model;generalized estimation equation;SCL-90;SF-36 |
| Author Name | Affiliation | E-mail | | LIANG Xinyu | Dalian Medical University, Dalian 116044, China | | | WANG Hongwu | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | DENG Bing | Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China | | | MAO Meijiao | Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China | | | DU Tinghai | The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 136300, China | | | LI Bin | The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 136300, China | | | YANG Baoping | Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730699, China | | | YU Yan | Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730699, China | | | ZHANG Hong | Tianjin Nankai Hospital, Tianjin 300100, China | | | ZHANG Shishu | Tianjin Nankai Hospital, Tianjin 300100, China | | | MAO Jingyuan | The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | WANG Xianliang | The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | XU Qiang | The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300150, China | | | ZHANG Lei | The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300150, China | | | SONG Guangming | Tianjin Wuqing Hospital of Traditional Chinese Medicine, Tianjin 301700, China | | | TIAN Li | Tianjin Wuqing Hospital of Traditional Chinese Medicine, Tianjin 301700, China | | | LI Peng | Dalian Medical University, Dalian 116044, China | | | LIU Jialin | Dalian Medical University, Dalian 116044, China | | | WANG Li | Tianjin Second People Hospital, Tianjin 300192, China | | | GAO Shan | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Lin | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | GAO Shuming | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | XU Yilan | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | PAN Ye | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | CAI Xuemeng | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Shuo | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | BIAN Yuhong | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Xiaofeng | Dalian Medical University, Dalian 116044, China
Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | lxf_chen@163.com | | YU Chunquan | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | ycq-4@163.com |
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| Abstract
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| [Objective] This study aimed to evaluate the effects of Tongmai Yangxin Pills in the treatment of qi and yin deficiency syndrome by comparing the linear mixed model and generalized estimating equation. The effects of different models,the degree of variation,and the applicability of models were examined by using clinical repeated measurement data.[Methods] This study was a multi-center,finess interventional study. A total of 83 individuals were enrolled from 7 clinical units. Four individuals were lost due to incomplete visiting and 79 individuals were finally included in this study. Among those individuals,39 were qi and yin deficiency syndrome of coronovy heart disease,receiving conventional Western medicine treatment,and traditional Chinese medicine Tongmai Yangxin Pills;and 40 were healthy people without any intervention. The scores of SCL-90 scale and SF-36 scale in different groups were compared at each time points. Coronary heart disease patients were measured in week 0,4,8 and 12 respectively;and the healthy people were considered on the level of 0 week.[Results] In this study,the total scores of the SCL-90 scale in the linear mixed model were correlated with the total score,time and gender of the SF-36 scale (P<0.05). The total scores of the SCL-90 scale in the generalized estimating equation were respectively the total score,gender and DBP of the SF-36 scale were correlated (P<0.05).[Conclusion] Tongmai Yangxin Pills showed its efficacy. The scale of SCL-90 and SF-36 provided the evidence for the clinical diagnosis and treatment of stable angina pectoris of coronary heart disease. The data in this study obtained precise results by the generalized estimation equation analysis. |
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