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| Effect of Panax notoginsenosides on pharmacokinetics of periplocin metabolite of periplocymarin |
| Hits 1642 Download times 1200 Received:December 25, 2018 |
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| DOI
10.11656/j.issn.1672-1519.2019.06.22 |
| Key Words
periplocymarin;Panax notoginsenosides;LC-MS/MS;pharmacokinetics |
| Author Name | Affiliation | E-mail | | LI Li | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | JIA Qi | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | YAO Guangzhe | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | OUYANG Huizi | The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | CHANG Yanxu | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | HE Jun | Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | hejun673@163.com |
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| Abstract
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| [Objective] To study the effect of Panax notoginsenosides on pharmacokinetics of periplocin metabolite of periplocymarin in rats.[Methods] Eighteen rats were divided into periplocin alone group;periplocin combined with low-and high-dose Panax notoginsenosides groups. All rats were orally administered for seven consecutive days,blood samples were obtained from orbitalis at different time before and after the last time administration. After that,the concentration of periplocymarin in plasma was determined,and main pharmacokinetic parameters of analyte were processed.[Results] Results of pharmacokinetics showed that there were significant differences between the pharmacokinetic parameters of periplocin metabolite of periplocymarin in rats as Cmax,Tmax,AUC0-t and AUC0-∞ with or without Panax notoginsenosides.[Conclusion] The compatibility of Periplocin and Panax notoginsenosides can change the pharmacokinetic behavior of periplocin metabolite of periplocymarin. |
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