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| Clinical observation of Bufei Huoxue Decoction in the treatment of stable chronic obstructive pulmonary disease |
| Hits 1669 Download times 1149 Received:January 20, 2019 |
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| DOI
10.11656/j.issn.1672-1519.2019.07.07 |
| Key Words
chronic obstructive pulmonary disease;Bufei Huoxue Decoction;efficacy;lung function;interleukin-8;α1-antitrypsin |
| Author Name | Affiliation | | LIU Yaru | First Department of Internal Medicine, Chengde Traditional Chinese Medicine Hospital, Chengde 067000, China | | LIU Yujing | First Department of Internal Medicine, Chengde Traditional Chinese Medicine Hospital, Chengde 067000, China | | JI Pinchuan | Department of Geratology, Chengde Traditional Chinese Medicine Hospital, Chengde 067000, China |
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| Abstract
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| [Objective] To explore the clinical efficacy of Bufei Huoxue Decoction in the treatment of stable chronic obstructive pulmonary disease (COPD). [Methods] A total of 103 patients with stable COPD from January 2016 to December 2017 were enrolled in this study. According to the random number table method,the subjects were divided into the control group (n=51) and the treatment group (n=52). The patients in the control group were given routine treatment. The patients in the treatment group were treated with Bufei Huoxue Decoction on the basis of the treatment in the control group,and the two groups were treated continuously for 12 weeks. The clinical efficacy of the two groups after treatment was evaluated and compared. The score of TCM syndromes,6-minute walking distance and quality of life was evaluated before and after treatment. The first second forced expiratory volume (FEV1),forced vital capacity (FVC) and the ratio of FEV1 to FVC (FEV1/FVC) was measured before and after treatment. Serum level of interleukin-8 (IL-8) and α1-antitrypsin (α1-AT) was measured before and after treatment in both groups. The occurrence of serious adverse reactions during the treatment of the two groups was recorded. [Results] The total effective rate of the treatment group (88.46%) was higher than that of the control group (70.59%,P<0.05). After treatment,FEV1,FVC and FEV1/FVC in the two groups increased significantly compared with those in the same group before treatment (P<0.05),and the changes of FEV1,FVC and FEV1/FVC in the treatment group was better than those in the control group (P<0.05). After treatment,the level of serum IL-8 in both groups was lower than those before treatment in the same group (P<0.05),and serum α1-AT level was higher than those before treatment in the same group (P<0.05),and the change of serum IL-8 and α1-AT levels in the treatment group was better than those in the control group (P<0.05). There were no serious adverse reactions in both groups. [Conclusion] Bufei Huoxue Decoction is effective in treating stable COPD. It can improve lung function,exercise ability and quality of life. It is speculated that the mechanism of Bufei Huoxue Decoction may be related to inhibiting airway inflammation,and its safety is good. It is worth popularizing and applying in clinic. |
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