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| Clinical observation of Baiji Mixture combined with nystatin tablets in the treatment of candidal esophagitis with liver depression and spleen deficiency |
| Hits 1574 Download times 1244 Received:February 06, 2019 |
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| DOI
10.11656/j.issn.1672-1519.2019.07.08 |
| Key Words
candidal esophagitis;Baiji Mixture;nystatin tablet;liver depression and spleen deficiency |
| Author Name | Affiliation | | PEI Qiang | The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, China | | WU Yang | The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, China | | GUO Xiaohe | The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, China |
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| Abstract
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| [Objective] To observe the clinical efficacy of Baiji Mixture combined with nystatin tablets in the treatment of candidal esophagitis with liver depression and spleen deficiency. [Methods] The 70 patients with candidal esophagitis of liver depression and spleen deficiency were randomly divided into two groups (n=35). The control group was treated with fluconazole capsule,while the observation group was treated with Baiji Mixture combined with nystatin tablets for 2-4 weeks. The changes of TCM syndrome scores,gastroscopy results,comprehensive efficacy and adverse reactions were compared between the two groups before and after treatment. [Results] After 2 weeks of treatment,the scores of acid reflux/heartburn,epigastric/hypochondriac pain,post-sternal burning pain,diet deficiency,abdominal distension,abnormal stool,tongue,tongue coating,irritability/depression,frequent sighing,belching and total score in the observation group were significantly lower than those before treatment (P<0.05). After 2 weeks of treatment,the scores of acid reflux/heartburn,epigastric/hypochondriac pain,post-sternal burning pain,dietary deficiency,abdominal distension,abnormal stool,tongue,tongue coating,irritability/depression and total score in the control group were significantly lower than those before treatment (P<0.05). The observation group was superior to the control group in improving epigastric/hypochondriac pain,post-sternal burning pain,diet deficiency,abdominal distension,abnormal stool,tongue,tongue coating,irritability/depression,and frequent sighing (P<0.05). The gastroscopic efficacy and comprehensive efficacy of the observation group were significantly better than those of the control group (P<0.05). [Conclusion] Baiji Mixture combined with nystatin tablets can significantly improve the clinical symptoms of patients with candidal esophagitis of liver depression and spleen deficiency,with definite antifungal effect and no obvious toxic and side effects. |
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