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| Antitumor activity of Cu(Ⅱ) complex with bioactive constituent Euxanthone from polygala |
| Hits 1391 Download times 1246 Received:March 20, 2019 |
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| DOI
10.11656/j.issn.1672-1519.2019.07.19 |
| Key Words
euxanthone;coordination chemistry of traditional Chinese medicine;cytotoxicity;DNA binding |
| Author Name | Affiliation | E-mail | | SONG Lulu | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | YU Qiao | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | QI Xuejie | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | YANG Aihong | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Xinyang | Department of Chemical Engineering, Tianjin University Renai College, Tianjin 301636, China | | | SHEN Rui | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | shenr05@126.com | | KOU Xiaodi | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | xiaodikou2013@163.com | | ZHAO Lihua | Department of Chemical Engineering, Tianjin University Renai College, Tianjin 301636, China | |
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| Abstract
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| [Objective] To study of cytotoxic activity and DNA-binding properties of Euxanthone Cu(Ⅱ) complex. [Methods] Three tumor cell lines including esophagus cancer (ECA109),stomach cancer (SGC7901) and cervical cancer (Hela) are used to evaluate the cytotoxic activities of Euxanthone Cu(Ⅱ) complex by MTT. The interactions of Euxanthone Cu(Ⅱ) complex with calf thymus DNA are investigated by fluorescence emission,ultraviolet absorption and circular dichroic spectra. [Results] Euxanthone Cu(Ⅱ) complex exhibits more effective inhibition activity against three cancer cells than Euxanthone and can intercalate into the DNA base pairs. [Conclusion] Euxanthone Cu(Ⅱ) complex could intercalate between DNA base pairs and cause DNA damage in cancer cells,thus inhibiting the division of cancer cells. |
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