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| Chinese medicine for treating cervical high-risk HPV infection: a systematic review |
| Hits 1467 Download times 1361 Received:March 16, 2019 |
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| DOI
10.11656/j.issn.1672-1519.2019.08.13 |
| Key Words
traditional Chinese medicine;cervical high-risk human papillomavirus infection;HR-HPV;systematic review;Meta-analysis |
| Author Name | Affiliation | E-mail | | HU Haiyin | Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | JI Zhaochen | Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Hucheng | Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Lishuang | Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Junhua | Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHENG Wenke | Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Hui | Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | wanghui1983@foxmail.com |
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| Abstract
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| [Objective] To evaluate the efficacy and safety of Chinese medicine on the treatment of cervical high-risk human papillomavirus infection (cervical hr-HPV infection).[Methods] CNKI,Wanfang,VIP,Sinomed,PubMed and The Cochrane Library from the inception to September 2018 were searched,and randomized controlled trials (RCTs) of Chinese medicine treating cervical high-risk HPV infection were collected. Two reviewers independently screened literature out and extracted data. The quality of inclusion studies was assessed using the bias risk assessment tool recommended by the Cochrane Handbook of Systematic Review,the dispute resolved through discussion or consulted with the third reviewers.[Results] The 3 015 literature were searched,14 RCTs were screened out according to the inclusion criteria,and 1 394 patients were included in this study. The result of meta-analysis showed that fourteen studies reported negative rates. One subgroup showed that Chinese medicine is significantly effective in increasing HR-HPV negative rate[RR=2.63,95%CI (1.96,3.52),P<0.000 01],while another subgroup showed that Chinese medicine was superior to Western medicine[RR=1.34,95%CI (1.09,1.64),P=0.005]. Eleven studies reported the total effective rate and five studies reported improvements in cervical inflammation scores,those all suggested that Chinese medicine is certainty effective on cervical high-risk human papillomavirus infection diseases. Two studies reported "no adverse reactions". Two studies reported adverse reactions including local tingling,swelling,flushing,erosion and pruritus.[Conclusion] Chinese medicine is effective in the prevention and treatment of cervical high-risk human papillomavirus infectious diseases. Due to the few high quality RCTs in traditional Chinese medicine,more high quality RCTs are needed to verify the above conclusion. |
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