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| Effects of different doses of total ginsenoside of ginseng stems and leaves on the pharmacokinetics of aspirin in rats |
| Hits 1427 Download times 1181 Received:May 04, 2019 |
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| DOI
10.11656/j.issn.1672-1519.2019.08.20 |
| Key Words
ginsenoside of stems and leaves;aspirin;salicylic acid;pharmacokinetics |
| Author Name | Affiliation | E-mail | | MO Yujia | School of Chinese Materia Medical, Beijing University of Chinese Medicine, Beijing 100029, China | | | XUE Yutao | School of Chinese Materia Medical, Beijing University of Chinese Medicine, Beijing 100029, China | | | TAN Li | School of Chinese Materia Medical, Beijing University of Chinese Medicine, Beijing 100029, China | | | YU Gangyan | School of Chinese Materia Medical, Beijing University of Chinese Medicine, Beijing 100029, China | | | DONG Ziyi | School of Chinese Materia Medical, Beijing University of Chinese Medicine, Beijing 100029, China | | | ZHANG Qi | School of Chinese Materia Medical, Beijing University of Chinese Medicine, Beijing 100029, China | | | LU Yang | School of Chinese Materia Medical, Beijing University of Chinese Medicine, Beijing 100029, China | landocean28@163.com | | DU Shouying | School of Chinese Materia Medical, Beijing University of Chinese Medicine, Beijing 100029, China | dushouying@263.net |
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| Abstract
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| [Objective] To study the effects of different concentrations of total ginsenoside of ginseng stems and leaves (TGSL) on the pharmacokinetics of aspirin in the metabolite salicylic acid in rats.[Methods] The 30 SD rats were randomly divided into the aspirin single-use group,the low,medium and high doses of TGSL combined group,and the long-term TGSL group. The 0.5 mL of blood samples was taken from the eye-lids at 0.083,0.25,0.5,1,2,4,6,8 and 10 h after intragastric administration. The plasma concentration of aspirin metabolite-salicylic acid in rat plasma was measured by HPLC-UV,and the pharmacokinetic parameters of salicylic acid were calculated by the non-compartmental model of DAS 3.0 software.[Results] Compared with aspirin group,TGSL at low dose (20 mg/kg) and medium dose (40 mg/kg) had no significant effect on the pharmacokinetics of aspirin in rats,but the combined use of high dose (80 mg/kg) of TGSL with aspirin significantly increased Cmax and AUC(0-t) of salicylic acid in vivo,and significantly decreased V and CL (P<0.05). The Cmax and AUC(0-t) of salicylic acid in vivo were also significantly increased under the long-term use of TGSL.[Conclusion] Within a certain dose range (40~80 mg/kg),TGSL can improve the plasma concentration of aspirin in vivo and increase its bioavailability,and there is a dose-dependent and time-dependent relationship. |
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