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| Research progress in inhibiting anti-apoptotic proteins of active components of traditional Chinese medicine for anti-tumor |
| Hits 1484 Download times 1356 Received:March 30, 2019 |
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| DOI
10.11656/j.issn.1672-1519.2019.08.23 |
| Key Words
traditional Chinese medicine;antitumor activity;anti-apoptotic proteins;research progress |
| Author Name | Affiliation | E-mail | | ZHANG Hongyang | Department of Chinese Medicinal Chemistry, College of Traditional Chinese Materia Medical, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Tianjin Key Laboratory of Modern Traditional Chinese Medicine, Tianjin 301617, China | | | CAO Shijie | Tianjin Key Laboratory of Modern Traditional Chinese Medicine, Tianjin 301617, China | | | QIU Feng | Department of Chinese Medicinal Chemistry, College of Traditional Chinese Materia Medical, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | fengqiu20070118@163.com | | KANG Ning | Department of Biochemistry, College of Integrated Traditional Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | kangndd@163.com |
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| Abstract
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| Tumorigenesis is the result of imbalance between cell proliferation and apoptosis. One of the important mechanisms of anti-apoptosis in tumor tissue is that tumor cells become resistant to apoptosis by expressing anti-apoptotic proteins. In recent years,the cancer therapy targeting the anti-apoptotic protein has attracted much attention in clinic research. The main anti-apoptotic proteins are B-cell lymphoma-2 (Bcl-2) involved in endogenous apoptosis pathway,apoptosis inhibitor proteins (IAPs) and cellular FADD-like IL-1β-converting enzyme-inhibitory protein (c-FLIP) which is involved in exogenous apoptosis pathway. The exploration of anti-tumor drugs with high efficiency and low toxicity has always been a research hotspot in tumor therapy. The natural active components of traditional Chinese medicine (TCM),which inhibit anti-apoptotic proteins,have become a new trend of modern anti-tumor drugs. Herein,to provide references and theoretical basis for the discovery and clarify the mechanism of novel anti-tumor drugs from TCM,we reviewed and summarized the chemical composition and molecular mechanisms of the active components from TCM and natural products that inhibit anti-apoptotic proteins. |
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