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| Literature study on the modeling of chronic atrophic gastritis and precancerous lesions in rats |
| Hits 1714 Download times 1432 Received:April 20, 2019 |
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| DOI
10.11656/j.issn.1672-1519.2019.09.05 |
| Key Words
chronic atrophic gastritis;precancerous lesions;rat;building method;literature study |
| Author Name | Affiliation | E-mail | | CHEN Zehui | Beijing University of Chinese Medicine, Beijing 100029, China | | | WEI Yue | Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing 100029, China | | | AN Jing | Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing 100029, China | | | PENG Jisheng | Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing 100029, China | | | HUANG Dawei | Zhejiang Traditional Chinese Medicine Hospital, Hangzhou 310006, China | | | JIA Yunfei | Henan Traditional Chinese Medicine Hospital, Zhengzhou 450002, China | | | YANG Jinxiang | Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing 100029, China | yjx571102@163.com |
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| Abstract
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| [Objective] Through the collation of related literatures,to study the current status of the modeling methods of chronic atrophic gastritis (CAG) and precancerous lesions (PLGC) in rats,and to provide useful guidance for further improving the animal model of this disease.[Methods] A comprehensive search of CNKI,VIP and Wanfang Database Self-built Library to July 31,2018 on experimental study of chronic atrophic gastritis and precancerous lesions in rats,including relevant literature for analysis.[Results] A total of 140 literatures were included,including 153 modeling methods. The modeling method is mostly used in compound factor modeling,and MNNG is the main modeling drug. In the aspect of modeling cycle,the average period of single factor and compound factor modeling was not statistically different.[Conclusion] The establishment of CAG model has the characteristics of longer period and higher mortality,and the establishment of stable and ideal experimental animal model still needs to be further explored. |
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