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| Excavation and analysis of the medication rules of ancient and modern doctors in treating depression |
| Hits 1288 Download times 967 Received:April 19, 2019 |
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| DOI
10.11656/j.issn.1672-1519.2019.09.06 |
| Key Words
depression;data mining;ancient book;famous old Chinese medicine;literature;medication rule;analysis |
| Author Name | Affiliation | E-mail | | YUAN Jie | Shaanxi Province Hospital of Traditional Chinese Medicine, Xi'an 710003, China | | | LEI Yaling | Shaanxi Province Hospital of Traditional Chinese Medicine, Xi'an 710003, China | 624552101@qq.com | | CAI Yihang | The Second Clinical Medical School of Guangzhou University Chinese Medicine, Guangzhou 510120, China | | | CHEN Yang | The Clinical Medical School of Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, China | | | WANG Pei | Shaanxi Province Hospital of Traditional Chinese Medicine, Xi'an 710003, China | | | HAN Zucheng | Shaanxi Province Hospital of Traditional Chinese Medicine, Xi'an 710003, China | |
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| Abstract
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| [Objective] To explore and analyze the medication rules of ancient and modern doctors in the diagnosis and treatment of depression.[Methods] Establish a database of ancient and modern doctors to treat depression,and use relevant software to analyze and compare using frequency statistics,cluster analysis and association rules.[Results] First,frequency analysis:the top 10 frequencies of ancient Chinese medicine used were licorice,xiangfu,tangerine peel,medlar,chuanxiong,medlar,atractylodes,pinellia,ginger and angelica;the contemporary literature was bupleurum,radix paeoniae,radix glycyrrhizae,angelica,Xiangfu,turmeric,salvia,atractylodes,medlar,and tangerine peel. Second,cluster analysis:astragalus and coptis in ancient literature,green skin and clam shell,atractylodes and ginseng,white peony and bupleurum,fragrant and Chuanxiong;atractylodes and divine comedy,Fuling and pinellia. In the contemporary literature,clams and chuanxiong,atractylodes and poria,Baizhu and angelica,Yujin and salvia were clustered together. Third,correlation analysis:the main related drugs in ancient books are Xiangfu,chuanxiong,pinellia,licorice,medlar,atractylodes,tangerine peel and medlar. The related drugs in the contemporary literature were bupleurum,angelica,licorice,poria,Xiangfu,and atractylodes.[Conclusion] Ancient and modern doctors believe that liver qi stagnation is the main pathogenesis of depression,and it is the main treatment for tonifying the liver and strengthening the spleen. However,ancient doctors pay more attention to qi,and the ingredients are more abundant. Contemporary doctors only prefer to soothe the liver. The ancient doctors used Xiangfu,Chuanxiong,pinellia,licorice,medlar,atractylodes,tangerine peel and medlar as the main medicine,reflecting the essence of the prescription of Yueqi Pills. Contemporary medical doctors use bupleurum,angelica,licorice,poria,Xiangfu and atractylodes as the core prescriptions,which are completely consistent with Xiaoyao San. For the diagnosis and treatment of depression,both ancient literature and contemporary Chinese and traditional Chinese medicine experience have the value of clinical reference. |
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