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| Xuefu Zhuyu Recipe for the treatment of essential hypertension: a systematic review and Meta-analysis |
| Hits 1935 Download times 1118 Received:April 16, 2019 |
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| DOI
10.11656/j.issn.1672-1519.2019.09.13 |
| Key Words
Xuefu Zhuyu Recipe;hypertension;systematic review;Meta-analysis |
| Author Name | Affiliation | E-mail | | CHEN Shanfu | Postgraduate School, Tianjin University of Chinese Medicine, Tianjin 301617, China | | | LI Tian | No.2 Department of Cardiovascular, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | LI Menglei | Postgraduate School, Tianjin University of Chinese Medicine, Tianjin 301617, China | | | LI Juan | Postgraduate School, Tianjin University of Chinese Medicine, Tianjin 301617, China | | | ZHAO Yingqiang | No.2 Department of Cardiovascular, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | zhaoyingqiang1000@126.com |
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| Abstract
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| [Objective] To evaluate the current clinical evidence for Xuefu Zhuyu Recipe (including decoction,capsules,pills,tablets,granules) in the treatment of essential hypertension.[Methods] Seven electronic databases including Cochrane Library,PubMed,EMBASE,CNKI,Weipu,Wanfang Database and CBM were searched. The search date was until December 2018,and all RCTs should be included in the Xuefu Zhuyu Recipe alone or in combination with antihypertensive drugs versus antihypertensive drugs in control. Assessing the methodological quality of the literature,extracting valid data and systematically evaluating it according to the Cochrane systematic review method. Outcome measures include antihypertensive effect,systolic blood pressure and diastolic blood pressure,TCM syndrome efficacy and adverse reactions.[Results] Meta-analysis of antihypertensive efficacy showed that OR=3.32,95%CI[2.00,5.50],P<0.000 01,the difference was statistically significant. Meta-analysis of systolic blood pressure showed that MD=-5.64,95% CI[-8.10, -3.17],P<0.000 01,and the difference between the two groups was statistically significant. Metastatic pressure Meta-analysis showed that MD=-3.42,95%CI[-4.61,-2.24],P<0.00001,and the difference between the two groups was statistically significant. Meta-analysis of TCM syndrome efficacy showed that OR=3.57,95%CI[2.09,6.11],P<0.000 01,and the difference was statistically significant;Meta-analysis of adverse reactions showed OR=1.34,95%CI[0.44,4.09],P=0.6,the difference was not statistically significant.[Conclusion] Xuefu Zhuyu Recipe combined with antihypertensive drugs is superior to simple antihypertensive drugs in reducing blood pressure,improving curative effect and improving TCM syndromes. There is no obvious adverse reaction. But the quality of the literatures currently included is uneven,and the interventions are not completely consistent,and further research is needed. |
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