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| Experimental study on effect of Shenqi Yangxin Granule on dogs with acute myocardial ischemia caused by coronary ligation |
| Hits 1349 Download times 934 Received:May 15, 2019 |
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| DOI
10.11656/j.issn.1672-1519.2019.09.20 |
| Key Words
Shenqi Yangxin Granule;acute myocardial ischemia;Beagle dog |
| Author Name | Affiliation | E-mail | | HAN Xiaojiang | Department of Traditional Chinese Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010059, China | | | DU Jinhui | Department of Traditional Chinese Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010059, China | gjzh195824@163.com | | GUAN Jingzhi | Department of Pharmacy, Inner Mongolia International Mongolian Hospital, Hohhot 010065, China | | | BI Lianbao | Department of Traditional Chinese Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010059, China | | | LIU Yanfei | Department of Imaging, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010059, China | | | Hugejile | Department of Clinical Laboratory, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010059, China | |
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| Abstract
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| [Objective] To study the effects of Shenqi Yangxin Granule on acute myocardial ischemia in dogs induced by coronary artery ligation.[Methods] Acute myocardial ischemia was induced by coronary artery ligation. The effects of Shenqi Yangxin Granule on N-ST,coronary vascular resistance,myocardial blood flow,myocardial oxygen consumption and myocardial infarct size were observed.[Results] Compared with the model control group,the Shenqi Yangxin granules in the middle dose group (5.46 g crude drug/kg) and the Shenqi Yangxin Granule high dose group (10.92 g crude drug/kg) significantly reduced the N-ST in the canine myocardial ischemic area. Compared with the model control group,the Shenqi Yangxin Granules middle dose group (5.46 g crude drug/kg) and Shenqi Yangxin Granule high dose group (10.92 g crude drug/kg) can significantly reduce coronary vascular resistance. Compared with the model control group,the Shenqi Yangxin Granule middle dose group (5.46 g crude drug/kg) and the Shenqi Yangxin Granule high dose group (10.92 g crude drug/kg) significantly increased myocardial blood flow in the canine acute myocardial ischemia model. Compared with the model control group,the high dose group of Shenqi Yangxin Granule (10.92 g crude drug/kg) can significantly reduce myocardial oxygen consumption. Compared with the model control group,the Shenqi Yangxin Granule middle dose group (5.46 g crude drug/kg) and the Shenqi Yangxin Granule high dose group (10.92 g crude drug/kg) can significantly reduce the area of myocardial infarction.[Conclusion] Shenqi Yangxin Granule has protective effect on acute myocardial ischemia induced by coronary artery ligation. |
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