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| Study of the differences in bergapten metabolites in liver microsomes of different species and genera |
| Hits 1314 Download times 1018 Received:May 17, 2019 |
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| DOI
10.11656/j.issn.1672-1519.2019.09.21 |
| Key Words
bergapten;liver microsome;metabolite;species difference |
| Author Name | Affiliation | E-mail | | LIU Wenli | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHI Dexian | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
School of Biotechnology Food Science, Tianjin University of Commerce, Tianjin 300134, China | | | WANG Lili | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LIU Changxiao | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China | | | HE Xin | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China | hexintn@163.com |
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| Abstract
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| [Objective] To study the differences in bergapten metabolites in seven liver microsomes.[Methods] Liver microsomes were incubated in vitro to study the metabolic differences in liver microsomes of seven species of animals. The metabolites of bergapten incubated in different species of liver microsomes were detected by Q-TOF-LC/MS.[Results] After incubation of bergapten with liver microsomes of seven species,four kinds of metabolites were detected. By comparing and analyzing the types and quantities of metabolites,the metabolism of bergapten in liver microsomes of beagle dog and rat are similar to that in human liver microsomes.[Conclusion] It was found that the metabolism of bergapten in liver microsomes of beagle dog and rat were similar to that in human liver microsomes. |
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