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| Clinical Study of Jiawei Suanzaoren Decoction combined with diazepam in the treatment of anxiety insomnia |
| Hits 1626 Download times 1089 Received:May 26, 2019 |
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| DOI
10.11656/j.issn.1672-1519.2019.10.05 |
| Key Words
anxiety insomnia;Jiawei Suanzaoren Decoction;diazepam;efficacy |
| Author Name | Affiliation | E-mail | | ZHANG Wen | First Ward, Wuhan Youfu Hospital, Wuhan 430023, China | | | ZHAN Cuiqin | First Ward, Wuhan Youfu Hospital, Wuhan 430023, China | | | ZHU Qianyun | First Ward, Wuhan Youfu Hospital, Wuhan 430023, China | 907443768@qq.com |
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| Abstract
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| [Objective] To explore the clinical efficacy of Jiawei Suanzaoren Decoction combined with diazepam in the treatment of anxiety insomnia.[Methods] One hundred patients with anxiety insomnia admitted to our hospital from January 2016 to May 2018 were enrolled in this study. The subjects were randomly divided into the control group (n=50) and the experiment group (n=50) randomly. The control group was treated with diazepam,while the experiment group was treated with Jiawei Suanzaoren Decoction combined with diazepam. The two groups were treated for 4 weeks. The clinical efficacy of the two groups was compared. The score of Hamilton Anxiety Scale (HAMA),Self-rating Anxiety Scale (SAS),Pittsburgh Sleep Quality Index (PSQI),serum dopamine (DA),5-hydroxytryptamine (5-HT),tumor necrosis factor-α(TNF-α) and peripheral blood CD4+,CD8+ level and CD4+/CD8+ ratioswas were compared before and after treatment.[Results] The total effective rate of the experiment group was 94.00% (47/50),which was significantly higher than 76.00% (38/50) of the control group (χ2=6.353,P=0.012). After treatment,the HAMA score,SAS score,PSQI score of the two groups was significantly lower than before treatment (P<0.05),and the change of HAMA score,SAS score and PSQI score in the experiment group was significantly greater than those in the control group (P<0.05). After treatment,the level of serum DA,5-HT,CD4+ and CD4+/CD8+ ratio in both groups was significantly higher than those before treatment,while the level of serum TNF-α and CD8+ in peripheral blood was significantly lower than those before treatment. The change of serum DA,5-HT,TNF-α,CD4+,CD8+ level and CD4+/CD8+ ratio in the experiment group was significantly greater than those in the control group (P<0.05).[Conclusion] Jiawei Suanzaoren Decoction combined with diazepam can obviously improve sleep,alleviate anxiety,regulate the level of neurotransmitters,correct the disorder of cellular immune function,and has good safety. |
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