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| Repair of Zengye Tongfu Zhuyu Decoction enema therapy on intestinal barrier in septic patients with acute gastrointestinal injury |
| Hits 1402 Download times 1074 Received:August 29, 2019 |
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| DOI
10.11656/j.issn.1672-1519.2019.10.07 |
| Key Words
sepsis;acute gastrointestinal injury;enema;intestinal barrier |
| Author Name | Affiliation | E-mail | | GAO Weiwei | Department of Intensive Care Unit, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120, China | | | KAN Jianying | Department of Intensive Care Unit, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120, China | sadrose1983@126.com | | YU Naihao | Department of Intensive Care Unit, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120, China | |
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| Abstract
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| [Objective] To observe the impair of Zengye Tongfu Zhuyu Decoction enema therapy on intestinal barrier function in patients with sepsis.[Methods] Sixty septic patients with acute gastrointestinal injury admitted to department of intensive care unit of Tianjin academy of traditional Chinese medicine affiliated hospital from June 2016 to August 2018 were enrolled. They were divided into the treatment group and the control group randomly,and each had 30 cases. The patients in the control group were treated with western medicine alone,and the patients in the treatment group were treated with enema of Zengye Tongfu Zhuyu Decoction on the basis of western medicine,150 mL once,2 times a day. The patients in both groups were treated with 10 days as a course of treatment. The differences of AGI grading before and after treatment were observed. Before the treatment and at the 5th day and 10th day after treatment,the intra-abdominal pressure,TCM syndromes,APACHE Ⅱ score,intestinal barrier markers and inflammation markers level in the two groups were also observed.[Results] There was a statistically significant difference in AGI grading between the two groups (P<0.05). At 5th day and 10th day after treatment,the abdominal pressure,TCM syndromes,APACHE Ⅱ score,intestinal barrier marker level,and inflammation index level of the two groups of patients were all significantly lower than the pre-treatment level,and the above indicators in the treatment group decreased significantly. Compared with the control group,the difference was statistically significant (P<0.05).[Conclusion] On the basis of simple western medicine treatment,the combined treatment of enema of Zengye Tongfu Zhuyu Decoction can improve and repair intestinal barrier in septic patients with acute gastrointestinal injury. |
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