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| Traditional Chinese medicine external therapy for constipation irritable bowel syndrome: a Meta-analysis and trial sequential analysis |
| Hits 1451 Download times 1005 Received:June 13, 2019 |
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| DOI
10.11656/j.issn.1672-1519.2019.10.12 |
| Key Words
traditional Chinese medicine external treatment;constipation-type of irritable bowel syndrome;randomized controlled trial;meta-analysis |
| Author Name | Affiliation | E-mail | | LYU Zhihao | The First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, China | | | LIANG Yuqi | Institute of Spleen and Stomach, Guangzhou University of Chinese Medicine, Guangzhou 510515, China | | | LI Huixuan | Institute of Spleen and Stomach, Guangzhou University of Chinese Medicine, Guangzhou 510515, China | | | QIN Jingchun | Institute of Spleen and Stomach, Guangzhou University of Chinese Medicine, Guangzhou 510515, China | | | XIAN Baiqing | The First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, China | | | GUO Chang | The First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, China | | | LIU Huaxi | School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510405, China | | | WEN Bin | Institute of Spleen and Stomach, Guangzhou University of Chinese Medicine, Guangzhou 510515, China | | | HU Fengliang | Proctology Department The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, China | hahahu08@126.com |
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| Abstract
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| [Objective] To evaluate the clinical efficacy of traditional Chinese medicine(TCM) external treatment in the treatment of constipation-type irritable bowel syndrome (IBS-C) using evidence-based medicine.[Methods] Randomized controlled trials (RCTs) of Chinese medicine and Chinese literature were retrieved from the Chinese and English databases of Pubmed,Embase,Cochrane library,Wan Fang,CNKI,VIP,CBM,etc. for the treatment of constipation-type irritable bowel syndrome. The data were extracted and RevMan 5.3 was used for data analysis.[Results] A total of 17 articles and 1 246 patients were included. Meta-analysis results indicated that the effective rate and cure rate of TCM treatment group were higher than those of western medicine control group,[OR=2.76;95% CI:2.01,3.79;P<0.000 01,OR=2.24;95% CI:1.63,3.08;P<0.000 01],and the recurrence rate was low[OR=0.14;95% CI:0.05,0.39;P=0.000 2];the overall symptom score of TCM treatment group was significantly lower than that of western medicine group,[MD=1.58;95% CI:1.46,1.69;P<0.000 01],and the improvement of defecation and abdominal pain were also better than the western medicine group[MD=0.30;95% CI:0.12,0.47;P=0.000 8,MD=0.43;95% CI:0.25,0.61;P<0.000 01]. However,there was no significant difference in the efficacy of the fecal traits between the two groups,[MD=-0.02;95% CI:-0.71,0.67;P=0.96]. TSA suggested that there was definite therapeutic efficacy evidence for TCM external treatment in the treatment of IBS-C.[Conclusion] The treatment of IBS-C with TCM external treatment is better than conventional western medicine,and it has higher safety and less adverse reactions. However,the above conclusions are still to be verified by more large-scale,multi-center,long-term high-quality RCT studies. |
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