|
| Analgesic effect and pharmacological mechanisms of Yuanhu Zhitong Oral Liquid on primary dysmenorrhea |
| Hits 2233 Download times 1327 Received:June 26, 2019 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2019.10.18 |
| Key Words
Yuanhu Zhitong Oral Liquid;oxytocin;primary dysmenorrhea;analgesic effect |
| Author Name | Affiliation | E-mail | | ZHANG Kai | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin Key Laboratory of Translational Research of TCM Prescription and Syndrome, Tianjin 301617, China | | | LI Nana | Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120, China | | | LI Song | Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | MENG Qingfen | Henan Fusen Pharmaceutical Co., Ltd., Henan 474450, China | | | GUAN Jianli | Henan Fusen Pharmaceutical Co., Ltd., Henan 474450, China | | | DENG Hao | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin Key Laboratory of Translational Research of TCM Prescription and Syndrome, Tianjin 301617, China | | | FAN Guanwei | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin Key Laboratory of Translational Research of TCM Prescription and Syndrome, Tianjin 301617, China
Institute of Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | fgw1005@hotmail.com |
|
| Abstract
|
| [Objective] To investigate the effects and pharmacological mechanisms of Yuanhu Zhitong Oral Liquid (YZOL) on primary dysmenorrhea and provide experimental basis for its clinical application.[Methods] The rat model of primary dysmenorrhea was induced by oxytocin. The writhing response was used as an indicator to investigate the effects of different doses of YZOL on dysmenorrhea rats. Plasma levels of estradiol (E2),progesterone (Prog),malondialdehyde (MDA),superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were measured in rats to explore the mechanisms of YZOL treatment. Moreover,the levels of prostaglandin F2α (PGF2α),prostaglandin E2 (PGE2),thromboxane B2 (TXB2),6-keto-prostaglandin F1α (6-keto-PGF1α),Ca2+ and nitric oxide (NO) in the uterus of rats were examined.[Results] YZOL could significantly reduce the writhing times (P<0.05) and writhing incidence of dysmenorrhea rats. Compared with the model group,significantly lower levels of MDA,PGF2α,Ca2+ (P<0.05) and markedly higher activity of 6-keto-PGF1α (P<0.05) were observed in the YZOL-treated group.[Conclusion] These results indicated that YZOL had a significant analgesic effect on the rat model of primary dysmenorrhea,and its mechanisms might be closely linked to the regulation of plasma MDA level and the levels of PGF2α,6-keto-PGF1α,Ca2+ in the uterine tissue. |
|
|
|
|
|
|
|
