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| Study on the clinical efficacy of Jieyu Pill combined with paroxetine in the treatment of post-stroke depression |
| Hits 1366 Download times 1143 Received:June 18, 2019 |
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| DOI
10.11656/j.issn.1672-1519.2019.11.07 |
| Key Words
post-stroke depression;Jieyu Pill;negative emotion;prospective cohort study |
| Author Name | Affiliation | E-mail | | TANG Xianqun | The First Clinical Medical College of Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, China | | | HAN Zucheng | Department of Brain Disease, Shanxi Provincial Chinese Medicine Hospital, Xi'an 710003, China | 13759968645@139.com | | CHEN Jun | Department of Brain Disease, Shanxi Provincial Chinese Medicine Hospital, Xi'an 710003, China | |
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| Abstract
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| [Objective] To observe the clinical efficacy and safety of Jieyu Pill combined with paroxetine in the treatment of post-stroke depression by prospective cohort study.[Methods] This study selected 360 patients who were hospitalized from January 2017 to September 2018 who met the inclusion and exclusion criteria. The patients were divided into the experimental group and the control group according to whether the patients accept Chinese medicine treatment. The control group was given basic medical treatment,rehabilitation treatment and paroxetine antidepressant treatment,and the observation group was given oral treatment of Jieyu Pill on the basis of the control group. Before and after intervention,the safety indexes of the National Institutes of Health Neurological Deficit Score (NIHSS),Hamilton Depression Scale (HAMD) and Self-rating Depression Scale (SDS) were compared between the two groups.[Results] The NIHSS score,HAMD score,and SDS scale scores of patients in the two groups were lower at 1 month and 3 months after intervention than those before treatment. After 1 month of intervention,there was no significant difference in NIHSS scale score,HAMD scale score and SDS scale score between the two groups (P>0.05); and after intervention for 3 months,there were statistically significant differences between the two groups in the evaluation of all scores (P<0.05). The total clinical effective rate was 90.00% in the treatment group after three months,which was significantly higher than 83.89% in the control group (P<0.05).[Conclusion] The clinical efficacy of Jieyu Pill combined with paroxetine in the treatment of post-stroke depression was better than that of paroxetine alone. |
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