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| Pathways and targets of Gusuibu in the treatment of osteoporosis based on systematic pharmacology |
| Hits 1510 Download times 1011 Received:May 20, 2019 |
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| DOI
10.11656/j.issn.1672-1519.2019.11.24 |
| Key Words
Gusuibu;osteoporosis;systemic pharmacology;pathway;target;mechanism |
| Author Name | Affiliation | E-mail | | ZHAO Jinlong | Second Clinical Medical College of Guangzhou University of Traditional Chinese Medicine, Guagnzhou 510405, China
Guangdong Academy of Traditional Chinese Medicine, Research Team on Bone and Joint Degeneration and Injury, Guangzhou 510120, China | | | ZENG Lingfeng | Guangdong Academy of Traditional Chinese Medicine, Research Team on Bone and Joint Degeneration and Injury, Guangzhou 510120, China
Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou 510120, China | | | ZHAO Di | Second Clinical Medical College of Guangzhou University of Traditional Chinese Medicine, Guagnzhou 510405, China
Guangdong Academy of Traditional Chinese Medicine, Research Team on Bone and Joint Degeneration and Injury, Guangzhou 510120, China | | | PAN Jianke | Guangdong Academy of Traditional Chinese Medicine, Research Team on Bone and Joint Degeneration and Injury, Guangzhou 510120, China
Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou 510120, China | | | HAN Yanhong | Second Clinical Medical College of Guangzhou University of Traditional Chinese Medicine, Guagnzhou 510405, China
Guangdong Academy of Traditional Chinese Medicine, Research Team on Bone and Joint Degeneration and Injury, Guangzhou 510120, China | | | LIANG Guihong | Guangdong Academy of Traditional Chinese Medicine, Research Team on Bone and Joint Degeneration and Injury, Guangzhou 510120, China
Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou 510120, China | | | LI Jiahui | Second Clinical Medical College of Guangzhou University of Traditional Chinese Medicine, Guagnzhou 510405, China
Guangdong Academy of Traditional Chinese Medicine, Research Team on Bone and Joint Degeneration and Injury, Guangzhou 510120, China | | | LIU Jun | Guangdong Academy of Traditional Chinese Medicine, Research Team on Bone and Joint Degeneration and Injury, Guangzhou 510120, China
Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou 510120, China | liujun.gdtcm@hotmail.com |
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| Abstract
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| [Objective] To explore the biological pathway and target of gusuibu in the treatment of osteoporosis by systematic pharmacology-related bioinformatics analysis.[Methods] The active constituents and target proteins of Gusuibu were extracted from TCMSP database. By using Cytoscape 3.5.1 to construct the relationship network between effective components and target of gusuibu for topological analysis. STRING10.5 database was used to construct and analyze protein-protein interaction (PPI) network. KEGG pathway function enrichment analysis was carried out with the help of David database.[Results] Naringin,eriodic tyol and kaempferol were the core compounds of Gusuibu. Prostaglandin G/H synthase 2,Heat shock protein HSP 90 and Caspase-3 were the important targets. JUN,TP53,MAPK1,IL-6,ESR1 were the key proteins in the effective components of gusuibu. KEGG results showed that osteoporosis mainly acted on TNF signaling pathway,T cell receptor signaling pathway,HIF-1 signaling pathway,PI3K-Akt signaling pathway,estrogen signaling pathway and other related signaling pathways.[Conclusion] Gusuibu has the biological effect of anti-osteoporosis through a variety of pathways and signaling pathways acting on a variety of targets. |
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