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| Mechanism of herb pair contining Hedyotis Diffusa-Scutellaria Barbata on colorectal cancer based on network pharmacology |
| Hits 2443 Download times 1091 Received:July 22, 2019 |
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| DOI
10.11656/j.issn.1672-1519.2019.12.21 |
| Key Words
Hedyotis Diffusa;Scutellaria Barbata;colorectal cancer;network pharmacology |
| Author Name | Affiliation | E-mail | | WANG Dandan | Department of Clinical Pharmacology, Luohe Central Hospital, Luohe 462300, China | | | GUO Lina | Department of Clinical Pharmacology, Luohe Central Hospital, Luohe 462300, China | | | TIAN Huidong | Department of Clinical Pharmacology, Luohe Central Hospital, Luohe 462300, China | | | YANG ZhongJie | Department of Clinical Pharmacology, Luohe Central Hospital, Luohe 462300, China | | | WANG Rui | Department of Clinical Pharmacology, Luohe Central Hospital, Luohe 462300, China | wangrui56189@163.com |
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| Abstract
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| [Objective] To investigate the compatibility mechanism and the material basis of colorectal cancer treatment by drug pair containing Hedyotis Diffusa and Scutellaria Barbat.[Methods] All the chemical components and the targets related to Hedyotis Diffusa and Scutellaria Barbat were searched by the traditional Chinese medicine system pharmacology platform (TCMSP),the oral bioavailability (OB) ≥ 30% and drug likeness (DL) ≥ 0.18 were used as the screening conditions for molecular compounds and the comparative Toxicogenomics Database (CTD) were used to screen the genes related to colorectal cancer. The network map construct by Cytoscape 3.6.1 software and the DAVID database for pathway annotation and analysis.[Results] The compounds-targets-pathway network of Hedyotis Diffusa-Scutellaria Barbat related to colorectal cancer contained 19 compounds,33 corresponding targets and 25 signaling pathway. The top three compounds were quercetin,baicalein,wogonin. The top three targets were AKT1,TP53,MMP-2. Related pathways were colorectal cancer,P53 signaling pathway,apoptosis.[Conclusion] The active components of Hedyotis Diffusa-Scutellaria Barbat regulate colorectal cancer,P53 signaling pathway,apoptosis in the treatment of colorectal cancer mainly through AKT1,TP53,MMP-2,MMP-9,and other targets. |
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