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| Effect and clinical efficacy of Xiaoyan Decoction combined with chemotherapy on peripheral blood vascular endothelial growth factor in patients with advanced non-small cell lung cancer |
| Hits 1423 Download times 893 Received:October 03, 2019 |
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| DOI
10.11656/j.issn.1672-1519.2020.01.09 |
| Key Words
Xiaoyan Decoction;advanced NSCLC;chemotherapy;angiogenesis;VEGF |
| Author Name | Affiliation | E-mail | | ZHU Jinli | Department of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China | | | ZHANG Shuo | The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | ZHANG Ying | Department of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China | | | LI Xiaojiang | Department of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China | | | JIA Yingjie | Department of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China | juju1130@126.com |
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| Abstract
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| [Objective] To observe the effect of Xiaoyan Decoction combined with chemotherapy on peripheral blood vascular endothelial growth factor (VEGF) in patients with advanced non-small cell lung cancer (NSCLC) and its clinical efficacy.[Methods] The 60 patients with advanced NSCLC were randomly divided into two groups:the observation group (30 cases) received GP regimen chemotherapy combined with oral Xiaoyan Decoction;the control group (30 cases) received chemotherapy alone. After two cycles of chemotherapy,the recent observable curative effect,improvement of symptoms,improvement of quality of life,changes of serum levels of vascular endothelial growth factor and toxic and side effects were observed.[Results] Xiaoyan Decoction combined with chemotherapy was superior to chemotherapy alone in stabilizing tumors,improving patients' chi-square scores and improving patients' quality of life. The difference between the two groups was statistically significant. Moreover,Xiaoyan Decoction combined with chemotherapy could significantly reduce the serum level of vascular endothelial growth factor,which had significant difference compared with chemotherapy alone. In terms of drug safety,Xiaoyan Decoction could significantly reduce the toxic side effects of chemotherapy,especially in the reduction of leukopenia,hemoglobin and other hemotoxicity improvement has a good clinical effect.[Conclusion] Xiaoyan Decoction combined with chemotherapy can alleviate the clinical symptoms of advanced NSCLC,improve KPS score,stabilize the lesion,inhibit the expression of vascular endothelial growth factor,alleviate the toxic side effects of hematopoietic system and improve the quality of life of patients. |
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