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| Efficacy and safety of Shuxuetong Injection for acute exacerbation of chronic cardiopulmonary disease:a systematic review |
| Hits 1334 Download times 900 Received:October 17, 2019 |
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| DOI
10.11656/j.issn.1672-1519.2020.01.13 |
| Key Words
Shuxuetong Injection;chronic pulmonary heart disease;pulmonary heart disease;systematic review;Meta-analysis |
| Author Name | Affiliation | E-mail | | WANG Hucheng | Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Keyi | Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Nan | Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | YANG Fengwen | Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | PANG Wentai | Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | JIN Xinyao | Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHENG Wenke | Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Junhua | Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | zjhtcm@foxmail.com |
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| Abstract
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| [Objective] To evaluate the efficacy and safety of Shuxuetong Injection in the treatment of acute exacerbation of chronic pulmonary heart disease.[Methods] CNKI,WanFang,SinoMed,VIP,PubMed,Cochrane library and EMbase databases were searched by computer,and the clinical randomized controlled trial(RCT) of Shuxuetong Injection for the treatment of acute exacerbation of chronic pulmonary heart disease was comprehensively collected. The retrieval time was from the building database to March 6,2019. Literature screening,data extraction and quality evaluation were conducted independently by 2 system evaluators according to inclusion and exclusion criteria. Literature methodology quality evaluation was conducted using the Cochrane handbook bias risk assessment tool. Meta-analysis using Revman 5.3 software and evaluation of outcome quality of outcome indicators with GRADE.[Results] A total of 9 RCTs were included. The results of the Meta-analysis showed that compared with the conventional Western medicine alone,the application of Shuxuetong Injection on the basis of conventional Western medicine treatment can further improve the clinical treatment effect (RR=1.29,95%CI[1.19,1.38],P<0.000 01). There were statistically significant differences in partial pressure of oxygen (MD=10.15,95%CI[9.16,11.14],P<0.000 01),partial pressure of Carbon Dioxide (MD=-6.63,95%CI[-7.31,-5.96],P<0.000 01) and blood viscosity. The GRADE evidence grading results show that the total effective rate,blood viscosity index evidence level is low,and the blood gas analysis index evidence level is extremely low. There was only one adverse event report in the trial group.[Conclusion] On the basis of the application of conventional Western medicine in the treatment of acute exacerbation of chronic pulmonary heart disease,Shuxuetong Injection can Improve the clinical efficacy,blood gas index and blood viscosity index. However,there are many methodological quality problems in the included studies,which will affect the reliability of the results of the literature. It needs to be further confirmed by large sample randomized controlled trials. |
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