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| Research progress on traditional Chinese medicine regulating endoplasmic reticulum stress in the prevention and treatment of diseases |
| Hits 1341 Download times 1065 Received:October 14, 2019 |
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| DOI
10.11656/j.issn.1672-1519.2020.01.24 |
| Key Words
traditional Chinese medicine;endoplasmic reticulum stress;apoptosis;autophagy |
| Author Name | Affiliation | | LIU Rong | Department of Traditional Chinese Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China | | TANG Fang | Department of Traditional Chinese Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China | | LING Haihui | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | LIANG Fen | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China |
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| Abstract
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| Increasing evidence shows that endoplasmic reticulum(ER) stress plays a critical role in the pathogenesis of numerous diseases. The unfolded protein response (UPR) signal pathways adjusts the expression of related genes to maintain the ER homeostasis or induce apoptosis if ER stress is still unsolved. Autophagy may be a compensatory mechanism for prolonged ER stress and is important for maintaining cell homeostasis. This paper reviews the effects of traditional Chinese medicine prescription,compounds and other treatments on diseases by regulating related signal pathways of ER stress and affecting apoptosis and/or autophagy in recent five years. We find that traditional Chinese medicine intervenes related genes of ER stress and have effects on numerous diseases. The functions mainly include:anti-tumor,protect nerve,protect heart muscle,protect liver cell,anti-tuberculosis,improve insulin resistance and so on. It provides potential new targets for the treatment of related diseases. |
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