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| Clinical study on the effect of Chaihu Shugan Powder on non-alcoholic steatohepatitis inflammatory factors |
| Hits 1213 Download times 855 Received:September 29, 2019 |
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| DOI
10.11656/j.issn.1672-1519.2020.02.16 |
| Key Words
Chaihu Shugan Powder;non-alcoholic steatohepatitis;inflammatory cytokines |
| Author Name | Affiliation | E-mail | | LUO Mingchi | The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | XUE Xiaoxue | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | CHENG Xufeng | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LIANG Rusheng | Tianjin First Hospital, Tianjin 300232, China | liangrusheng2000@163.com |
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| Abstract
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| [Objective] To further observe the efficiency of Chaihu Shugan Powder on inflammatory response factors in patients with non-alcoholic steatohepatitis (NASH) and its clinical effect.[Methods] The 160 patients with NASH who were treated from July 2014 to June 2016 were randomly divided into two groups. The observation group of 80 cases was treated with the classic prescription Chaihu Shugan Powder,and the control group of 80 cases was treated with colchicine,and the effect of the two groups was observed.[Results] The results of clinical trials showed that the total effective rate of Chaihu Shugan Powder treatment was significantly higher than that of the Silibinin control group,the difference was statistically significant (P<0.05). Compared with the Silibinin control group,the treatment of Chaihu Shugan Powder for 12 weeks and 24 weeks can significantly reduce the patients' symptom score and cumulative symptom score,improve the patients' liver function indicators Aspartate transaminase (AST),Alanine transaminase (ALT) and Total Bilirubin (TBIL),and the patients' lipid profile Triglyceride (TG) and Total Cholesterol (TC) and patients' fatness (CAP) levels (P<0.05),and reduced serum inflammatory factor Tumor necrosis factor-α (TNF-α),Interleukin-6 (IL-6),Interleukin-8 (IL-8) levels in NASH patients.[Conclusion] Chaihu Shugan Powder can improve clinical symptoms and liver function,blood lipid index,fatness of NASH patients,reduce inflammatory factor levels,protect the liver,and have good clinical efficacy. |
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