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| Analysis of the rule of medication for dampness syndrome in Zhonghua Yidian medical records based on complex network |
| Hits 1595 Download times 853 Received:December 10, 2019 |
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| DOI
10.11656/j.issn.1672-1519.2020.03.16 |
| Key Words
dampness syndrome;complex network;compatibility regularity;Zhonghua Yidian |
| Author Name | Affiliation | E-mail | | JIN Xinyao | Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Dong | Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Lishuang | Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | JI Zhaochen | Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Xiao | Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LYU Ling | Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHAO Mengyu | Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | PANG Wentai | Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Junhua | Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | zjhtcm@foxmail.com |
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| Abstract
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| [Objective] The study used complex network analysis methods to analyze the compatibility of Chinese medical treatment for dampness syndrome.[Methods] Extracted the drug information by retrieving the medical records included in the medical section of Zhonghua Yidian with the key word "dampness". The R Programming Language software Apriori algorithm was used for association analysis,and complex network analysis was implemented based on Gephi 0.9.2 software.[Results] The study included 453 medical records and 257 Chinese medicines. The frequency of medication was 3 321 times. Through analyzing the drug according to efficacy,medical properties and medical taste,the study found that a total of 16 inducing diuresis for eliminating dampness drugs were used,and the frequency of drug use was 619 times,accounting for 18.6%. The 75 warm drugs were used,with the use frequency of 1 062 times,accounting for 32%. The 120 tablets of bitterness were used,with the using frequency of 1701,accounting for 31.3%. The correlation analysis showed that Chen Pi-Fu Ling,Ze Xie-Fu Ling,Bai Zhu-Fu Ling,Hou Po-Fu Ling were the core drug pairs in the treatment of dampness syndrome. The correlation analysis results were calculated using Gephi 0.9.2 software,and finally 37 core drugs were obtained. Analyzing the results through modular processing and professional knowledge,the core components of the dampness syndrome treatment represented by Wuling San,Erchen Tang,Pingwei San,Huanglian Jiedu Tang and Sanren Tang were summarized. The core treatment methods such as inducing diuresis for eliminating dampness,invigorating spleen and draining dampness,invigorating spleen and drying dampness,bitter-cold herbs easing dampness,dispersing qi and resolving dampness and dispelling wind and eliminating dampness are presented.[Conclusion] Complex network analysis methods can be used to summarize the prescription rules and core treatment methods of ancient medical treatment of dampness syndrome. It can also provide reference for modern clinical practice and provide ideas for further exploration of traditional Chinese medicine(TCM) clinical experience in the future. |
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