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To explore the possibility of Carthamus tinctorius in the treatment of non-alcoholic fatty liver based on the network pharmacology
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DOI   10.11656/j.issn.1672-1519.2020.03.21
Key Words   Carthamus tinctorius;non-alcoholic fatty liver disease;network pharmacology;signaling pathway
Author NameAffiliationE-mail
DENG Nan Beijing University of Chinese Medicine, Beijing 100029, China  
FAN Shuning Beijing University of Chinese Medicine, Beijing 100029, China  
XU Tian Beijing University of Chinese Medicine, Beijing 100029, China  
CHENG Fafeng Beijing University of Chinese Medicine, Beijing 100029, China fafengcheng@gmail.com 
WANG Xueqian Beijing University of Chinese Medicine, Beijing 100029, China  
WANG Qingguo Beijing University of Chinese Medicine, Beijing 100029, China  
Abstract
    [Objective] To study the mechanism of Carthamus tinctorius in the treatment of non-alcoholic fatty liver through network pharmacology.[Methods] The effective active components of Carthamus tinctorius OB ≥ 30% and DL ≥ 0.18 were obtained through the pharmacology database of traditional Chinese medicine system and analysis platform (TCMSP) database. The corresponding target of components were obtained through Swiss target prediction database. Targets of non-alcoholic fatty liver were obtained by using DisGeNet database and OMIM database.The relationship network between interactive gene proteins was constructed by using STRING database,and the GO enrichment and KEGG signal pathways were analyzed by using DAVID database.[Results] The 361 targets of Carthamus tinctoriu were screened,including 38 targets involving non-alcoholic fatty liver,which were mainly related to VDR,PPARD,TNF,INSR and other targets. The results of KEGG enrichment analysis showed that the treatment of non-alcoholic fatty liver by Carthamus tinctoriu was related to insulin resistance,prolactin signaling pathway,PPAR signaling pathway and other pathways.[Conclusion] In this study,the active components of Carthamus tinctoriu and their corresponding targets were discussed through the network pharmacology system,as well as the potential pathways for the treatment of non-alcoholic fatty liver disease,providing reference for the in-depth study of the basic and clinical research on the treatment of non-alcoholic fatty liver disease.

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