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| Advances in the study of micro/nano oral colonic targeted delivery system in the treatment of inflammatory bowel disease |
| Hits 1903 Download times 816 Received:December 06, 2019 |
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| DOI
10.11656/j.issn.1672-1519.2020.03.26 |
| Key Words
micro/nano particle;inflammatory bowel disease;physiological factor of gastrointestinal tract;colon targeting;colonic delivery system |
| Author Name | Affiliation | E-mail | | ZHANG Wenyan | Chinese Medicine Research Institute, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Kuangdai | Chinese Medicine Research Institute, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Qiangsong | Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China | wangqiangsong2008@163.com;崔元璐，cuiyl@tju.edu.cn | | CUI Yuanlu | Chinese Medicine Research Institute, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | cuiyl@tju.edu.cn |
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| Abstract
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| The oral colon-targeted drug delivery system (OCTDDS) is designed to target the delivery of therapeutic agents to colonic disease sites to improve the effectiveness of drug treatment,reduce systemic side effects,increase bioavailability,which is beneficial for the treatment of inflammatory bowel disease (IBD). However,in a disease state,changes in the physiological environment of the gastrointestinal tract can affect the therapeutic efficacy of the drug. The long-term use of commonly used drugs for the treatment of IBD in clinical practice can cause serious systemic side effects. As a supplement and alternative medicine,Chinese medicine has attracted more and more researchers' attention. In recent years,micro-particles and nano-particles have gradually become effective tools for the treatment of IBD due to their relatively suitable particle size,long drug retention time,and controllable drug absorption rate. This article mainly reviews the physiological factors of gastrointestinal tract that affects oral drug delivery,the formulation design of micro/nano preparations and the research progress of pharmacodynamic effect to provide a reference for colonic targeted delivery of drugs with low oral bioavailability. |
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