|
| Effect of Bushen Jianpi Huoxue method on early hemopoietic recovery after immunosuppressive therapy for patients with severe aplastic anemia |
| Hits 2168 Download times 1345 Received:January 10, 2020 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2020.04.12 |
| Key Words
severe aplastic anemia;combined treatment of traditional Chinese medicine and Western medicine;immunosuppressive therapy |
| Author Name | Affiliation | E-mail | | TAN Xucheng | Hematology Department, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China | | | ZHAO Lin | Hematology Department, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China | | | ZHAO Yihan | Hematology Department, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China | | | QIU Zhongchuan | Hematology Department, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China | | | QU Weiying | Hematology Department, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China | | | ZHU Xiaoqin | Hematology Department, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China | | | ZHANG Wenjun | Hematology Department, Tongji Hospital of Tongji University, Shanghai 200092, China | | | LU Yong | Hematology Department, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China | wuyouwulv528@163.com |
|
| Abstract
|
| [Objective] To observe the clinical efficacy of immunosuppressive therapy combined with Bushen Jianpi Huoxue methodfor severe aplastic anemia (SAA) and its effect on T-lymphocyte subsets,and to explore its mechanism in promoting early hematopoietic recovery after IST of severe aplastic anemia.[Methods] Sixty SAA patients with SAA randomly divided into treatment group (n=30)and control group(n=30). The treatment group was treated with IST combined with traditional Chinese medicine therapy,while the control group was treated with IST combined with traditional Chinese medicine simulator. The treatment lasted for 3 months and follow-up visits lasted for 1 year.The clinical efficacy andthe changes of T lymphocytes subsetsbefore and after treatment were observed.[Results] The total effective rate in the treatment group was higher than that in the control group,but there was no significant difference(P>0.05).Aftertreatment,the blood cell counts in the two groups were improved compared with those of before treatment(P<0.05,P<0.01).The hemoglobin of treatment group was significantly higher than that of control group(P<0.05).Compared with the data before treatment in treatment group,the ratio of CD3+CD4-CD8+/CD3+CD19- cells and CD4+CD25+Foxp3+/CD4+CD25+cells decreased(P<0.05),and the ratio of CD4+CD25+Foxp3+ cells was lower than that in the control group(P<0.05).[Conclusion] The combination of IST and Bushen Jianpi Huoxue method is effective in the treatment of SAA,and its mechanism may be related to the decrease of CD8+ cells,the increase of CD4+ cells and the expression of Foxp3+. |
|
|
|
|
|
|
|
