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| Research progress on the role of NLRP3 inflammasome in atherosclerosis |
| Hits 1402 Download times 1051 Received:January 07, 2020 |
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| DOI
10.11656/j.issn.1672-1519.2020.04.24 |
| Key Words
NLRP3 inflammasome;inflammatory response;atherosclerosis;coronary atherosclerosis;intracranial atherosclerosis;diabetes |
| Author Name | Affiliation | E-mail | | XIE Jing | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | CHENG Qi | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LIU Yijia | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | GAO Shan | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | bianjibugs@163.com | | YU Chunquan | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | ycq-4@163.com |
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| Abstract
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| Nod-like receptor protein 3(NLRP3) inflammasome is an important component of NLR inflammatory pathway,which is composed of NLRP3 scaffold,ASC(apoptosis-associated speck-like protein containing CARD) and pro-Caspase-1. The activated NLRP3 inflammasome can enhance the inflammatory response by promoting the production and secretion of key downstream cytokines,such as Caspase-1,interleukin-1β(IL-1β),IL-18(interleukin-18),and so on. Thus,the inherent immunity and specific immunity of the body could be maintained. Studies have shown that NLRP3 inflammasome,as the most widely studied inflammasome and the cytokines that can affect the progress of atherosclerosis,immune diseases,inflammatory diseases and other types of diseases,has become a research hotspot in recent years. This article mainly discusses the regulatory effect of the activated NLRP3 inflammasome in atherosclerosis from the mechanisms of inflammatory response. |
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