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| Analysis of curative effect of 51 patients with novel coronavirus pneumonia treated with Chinese medicine Lianhua Qingwen:a multicentre retrospective study |
| Hits 1740 Download times 1257 Received:March 07, 2020 |
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| DOI
10.11656/j.issn.1672-1519.2020.05.06 |
| Key Words
COVID-19;novel coronavirus pneumonia;Lianhua Qingwen;clinical research;efficacy analysis;multicenter retrospective study |
| Author Name | Affiliation | E-mail | | CHENG Dezhong | Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan 430081, China | | | WANG Wenju | CR&WISCO General Hospital Affiliated to Wuhan University of Science and Technology, Wuhan 430080, China | | | LI Yi | Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan 430081, China | | | WU Xiaodong | CR&WISCO General Hospital Affiliated to Wuhan University of Science and Technology, Wuhan 430080, China | | | ZHOU Biao | Wuhan Ninth Hospital, Wuhan 430081, China | 66392841@qq.com | | SONG Qiyong | Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan 430081, China | 823571167@qq.com |
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| Abstract
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| [Objective] To analyze the clinical efficacy of combined application of Lianhua Qingwen Granules (LH-C) in the treatment of novel coronavirus pneumonia (NCP).[Methods] A retrospective clinical research method was adopted to select clinically eligible patients with novel coronavirus pneumonia (NCP) in the three hospitals of Puren Hospital Affiliated to Wuhan University of Science and Technology,CR & WISCO General Hospital,and Wuhan Ninth Hospital in January 2020. Among patients meeting inclusion and exclusion criteria,51 cases receiving LH-C combined with the conventional therapy were included in the treatment group,and 51 cases receiving the conventional therapy were included in the control group,with propensity matching 1:1. The disappearance rate,duration,and effective rate of cardinal symptoms (fever,fatigue,cough),other symptoms and signs disappearance rate,lung computer tomography (CT) improvement rate were compared between two groups.[Results] There were no significant differences in baseline between two groups. After 7 days of treatment,the disappearance rate of cardinal symptom (fever,fatigue,cough) in the treatment group was 83.7%,61.3%,and 62.2%,and the control group was 61.0%,34.3%,and 35.9%. There was a statistically significant difference between the two groups (P<0.05). The average disappearance time of cardinal symptom in the treatment group was (2.9±1.7),(3.5±1.5) and (3.9±2.0) days,and the control group was (3.9±1.3),(4.8±1.5) and (5.2±1.8) days,the difference between two groups was statistically significant (P<0.05). The cardinal symptoms of the treatment group were effective in 44 cases (86.3%) and the control group was 35 cases (68.6%),and the differences between two groups was statistically significant (P<0.05). The disappearance rate of expectoration,shortness of breath,chest distress,appetite loss,and moist rale sign was 55.0%,61.5%,54.6%,34.8% in the treatment group,and 15.8%,14.3%,15.8%,7.7% in the control group. There was a statistically significant difference between two groups (P<0.05). In the treatment group,4 cases (7.8%) were converted to heavy,and 11 cases (21.6%) in the control group. The difference between two groups was statistically significant (P<0.05). There were 28 cases (54.9%) of lung CT improvement in the treatment group and 23 cases (45.1%) in the control group. There was no significant difference between two groups (P>0.05).[Conclusion] LH-C combined with a conventional therapy could significantly improve clinical symptoms of NCP patients including fever,fatigue,cough,expectoration,shortness of breath,chest distress and appetite loss,enhance the effective rate of cardinal symptom,and reduce the proportion of normal to heavy. These findings suggested LH-C could be effective in the common NCP patients. |
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