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| Advances in the treatment of myocardial fibrosis by Tongxinluo Capsule |
| Hits 1181 Download times 939 Received:December 30, 2019 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2020.05.21 |
| Key Words
Tongxinluo Capsule;vessel-collateral theory;myocardial fibrosis;endothelial to mesenchymal transition;microcirculation |
| Author Name | Affiliation | E-mail | | LI Hongrong | Hebei Yiling Hospital, State Administration of Traditional Chinese Medicine, Traditional Chinese Medicine Collaterology Key Discipline, Shijiazhuang 050091, China | | | ZHAO Qifei | Hebei Yiling Hospital, State Administration of Traditional Chinese Medicine, Traditional Chinese Medicine Collaterology Key Discipline, Shijiazhuang 050091, China | | | YIN Yujie | Hebei Yiling Medical Research Institute, Key Laboratory of State Administration of Traditional Chinese Medicine, Shijiazhuang 050035, China | | | CHANG Liping | State Key Laboratory of Collateral Disease Research and Innovation of Traditional Chinese Medicine, Shijiazhuang 050091, China | | | JIA Zhenhua | Hebei Yiling Hospital, State Administration of Traditional Chinese Medicine, Traditional Chinese Medicine Collaterology Key Discipline, Shijiazhuang 050091, China | JZHjiazhenhua@163.com |
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| Abstract
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| Myocardial fibrosis is a common pathological change from the development of many cardiovascular diseases to the terminal stage. Coronary microcirculation disturbance caused by various causes,as well as the ischemia,inflammation,endothelial interstitial transdifferentiation and so on,are the important inducements of myocardial fibrosis. The Vessel-Collateral theory holds that choroid stasis caused by various causes is the central link of myocardial fibrosis. Tongluo representative prescription Tongxinluo Capsule has the protective effect of blood,blood vessels and heart,and can significantly improve coronary microcirculation. It can significantly inhibit myocardial fibrosis caused by diabetes mellitus,myocardial infarction,myocarditis and so on,and can effectively improve cardiac function. Microcirculation disorder can also cause pulmonary fibrosis cirrhosis and systemic sclerosis and other diseases. Tongxinluo Capsule may play a role in inhibiting pulmonary fiber cirrhosis and systemic sclerosis by improving tissue microcirculation. |
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