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| Study of the effect of marketed Chinese patent medicine on inhibiting collagen deposition in fibroblasts models |
| Hits 1610 Download times 937 Received:March 06, 2020 |
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| DOI
10.11656/j.issn.1672-1519.2020.06.06 |
| Key Words
Chinese patent medicine;fibroblasts;collagen deposition;COVID-19 |
| Author Name | Affiliation | E-mail | | YANG Jian | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | HAN Lifeng | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | SHAO Rui | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Peng | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | HAO Jia | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | CHANG Yanxu | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | GAO Xiumei | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Tao | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | wangtao@tjutcm.edu.cn |
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| Abstract
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| [Objective] The respiratory system infected by virus normally causes lung injury,subsequently followed by pulmonary fibrosis. This process is related to several pathological processes,such as recruitment of lung fibroblasts,collagen deposition and extracellular matrix remodeling. Currently,there is no effective therapeutic drugs in the clinic. This experiment was aim to get the marketed Chinese patent medicine with the effect of collagen deposition inhibiting.[Methods] In this paper,we screened marketed Chinese patent medicines by Sirius Red staining method using collagen deposition models of human-derived lung fibroblasts and murine-derived fibroblasts.[Results] A few marketed medicines with significant inhibition in collagen deposition both in embryonic fibroblast of mice and human fibroblasts models were screened out.[Conclusion] The results suggest that these marketed Chinese patent medicines are expected to have more promising clinical applications,and provide the basis for drug selection for the later COVID-19 rehabilitation treatment. |
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