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| The distribution of syndrome types of traditional Chinese medicine and clinical characteristics in 296 patients with diabetic nephropathy in stage Ⅲ-Ⅴ |
| Hits 1272 Download times 820 Received:January 18, 2020 |
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| DOI
10.11656/j.issn.1672-1519.2020.06.15 |
| Key Words
type 2 diabetic nephropathy;traditional Chinese medicine syndrome;clinical feature;deficiency syndrome;excessive pathogen syndrome |
| Author Name | Affiliation | E-mail | | TENG Fubin | Department of Nephrology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China | | | ZHANG Jingqian | Department of Cardiology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100700, China | | | SHI Anqi | Department of Acupuncture and Moxibustion, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China | | | YAO Jieqiong | No.1 Department of Nephropathy, Shanxi Hospital of Traditional Chinese Medicine, Shanxi Institute of Traditional Chinese Medicine, Taiyuan 030012, China | | | QI Xiaohuan | Department of Acupuncture and Moxibustion, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China | | | SUN Weiwei | Department of Nephrology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China | sunweitcm@163.com |
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| Abstract
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| [Objective] The purpose of this study is to explore and analyze the syndrome types of traditional Chinese medicine (TCM) and clinical characteristics in patients with diabetic nephropathy (stage Ⅲ-V),and to provide reference for the "syndrome association" in diabetic nephropathy and TCM syndrome types.[Methods] From August 2013 to February 2016,patients with stage Ⅲ-V diabetic nephropathy diagnosed in Dongzhimen Hospital of Beijing University of Chinese Medicine were selected. Patients were divided into qi deficiency group,blood deficience group,yin deficiency group,yang deficiency group,qi depression group,blood stasis group,dampness tubid group and heat group by syndiome characteristics. The clinical data were analyzed retrospectively,while the distribution and clinical characteristics of TCM syndromes were analyzed.[Results] With the progress of the disease,the proportion of blood deficiency syndrome and yang deficiency syndrome increased gradually,and the proportion of yin deficiency syndrome and heat syndrome decreased gradually. The course of disease in blood deficiency syndrome,yang deficiency syndrome and blood stasis syndrome were significantly longer (P<0.05). In the analysis of clinical characteristics,the deficiency syndrome groups,plasma albumin was significantly lower (P<0.05),24 h urinary protein quantity (P<0.05),the serum creatinine (Scr) and urea nitrogen (BUN) (P<0.01) were significantly higher in patients with blood deficiency syndrome and yang deficiency syndrome. The hemoglobin (Hb) in the blood deficiency group was lower than that in the other groups (P<0.01). The glycosylated hemoglobin (HbAlc) in qi deficiency group (P<0.05). Among the excessive pathogen syndrome,The Hb in qi depression and blood stasis group was significantly lower (P<0.05). The HbAlc in blood stasis group and heat group was higher (P<0.05). The Scr and BUN were higher in dampness turbid group (P<0.05),and BUN was higher in qi depression group (P<0.01).[Conclusions] With the progress of the disease,the righteous qi is becoming more and more deficient. The proportion of blood deficiency syndrome and yang deficiency syndrome is higher. Among them,blood deficiency syndrome and yang deficiency syndrome are associated with lower plasma albumin,higher 24 h urinary protein quantitative,higher serum creatinine and higher urea nitrogen. The high serum creatinine and urea nitrogen were found in dampness and turbidity syndrome. |
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