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| Clinical observation of Qingzhong Yiwei Decoction combined with quadruple therapy in the treatment of Hp related chronic gastritis |
| Hits 1436 Download times 913 Received:February 13, 2020 |
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| DOI
10.11656/j.issn.1672-1519.2020.06.16 |
| Key Words
Qingzhong Yiwei Decoction;Hp-related chronic gastritis;quadruple therapy;randomized control |
| Author Name | Affiliation | E-mail | | DUN Ze | Graduate School, Hebei University of Chinese Medicine, Shijiazhuang 050091, China | | | LIU Yanli | Graduate School, Hebei University of Chinese Medicine, Shijiazhuang 050091, China | | | ZHANG Yimeng | Graduate School, Hebei University of Chinese Medicine, Shijiazhuang 050091, China | | | MU Linlin | Graduate School, Hebei University of Chinese Medicine, Shijiazhuang 050091, China | | | JIA Sujie | Graduate School, Hebei University of Chinese Medicine, Shijiazhuang 050091, China | | | GUO Lifang | No.1 Department of Spleen and Stomach Diseases, Affiliated Hospital of Hebei College of Traditional Chinese Medicine, Shijiazhuang 050011, China | glf696@163.com |
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| Abstract
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| [Objective] To observe the clinical efficacy and safety of Qingzhong Yiwei Decoction in in patients with Helicobacter pylori (Hp) infection-associated chronic gastritis with spleen and stomach damp-heat syndrome.[Methods] A 6-week randomized,controlled clinical trial was conducted. The 88 cases of Hp-related chronic gastritis with spleen and stomach damp-heat syndrome were divided into the treatment group (44 cases) and the control group (44 cases) according to the random number table. The treatment group was treated with Qingzhong Yiwei Decoction plus quadruple drugs,while the control group was not treated with traditional Chinese medicine and was given oral quadruple drug alone. Both the treatment group and the control group were given the quadruple drugs for 2 weeks,and the treatment group was given Qingzhong Yiwei Decoction for 6 weeks,that is,after taking the quadruple,the drug was taken for 4 weeks. Before and after treatment,the classification of mucosal lesions,negative conversion rate of Hp infection,symptom score of traditional Chinese medicine and safety index after treatment were observed.[Results] A total of 81 eligible cases were finally included of 40 cases in the treatment group and 41 cases in the control group. Compared with the two groups before treatment,the symptom score of the treatment group,the evaluation of the graded lesion mucosal efficacy,and the negative conversion rate of Hp were better than those of the control group.[Conclusion] Qingzhong Yiwei Decoction can effectively improve the negative conversion rate of Hp,obviously improve the symptoms of patients,promote the repair of mucous membrane,and has higher safety. |
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