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| Study on the effect of Shaofu Zhuyu Decoction on promoting blood circulation in rats with primary dysmenorrhea of cold-coagulating blood stasis syndrome |
| Hits 1020 Download times 656 Received:April 20, 2020 |
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| DOI
10.11656/j.issn.1672-1519.2020.08.20 |
| Key Words
Shaofu Zhuyu Decoction;function of activating blood circulation;uterine blood flow;hemorheology;coagulation function;TXA2;PGI2 |
| Author Name | Affiliation | E-mail | | WU Zengguang | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | HU Peng | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | FAN Baishuang | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Sichao | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LIU Changxiao | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China | | | HE Xin | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China | hexintn@163.com |
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| Abstract
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| [Objective] To investigate the effect of Shaofu Zhuyu Decoction and its components in promoting blood circulation,removing blood stasis,and warming and analgesic pain blood circulation of primary dysmenorrhea rats with cold-coagulating blood stasis syndrome.[Methods] Rat models of primary dysmenorrhea with cold-coagulating blood stasis syndrome were prepared and divided into control group,model group,aspirin group,Shaofu Zhuyu Decoction full prescription group (Quanfang group),Shaofu Zhuyu Decoction activating blood circulation and removing blood stasis group (Huoxue group) and Shaofu Zhuyu Decoction in the Wenjing analgesia group (Wenjing group) for 7 consecutive days. The uterine blood flow and hemorheology (plasma viscosity,hematocrit,red blood cell aggregation index,red blood cell electrophoresis index,red blood cell deformation index),coagulation function (PT,TT,APTT,FIB),thromboxane (TXA2),and prostacyclin (PGI2) levels were evaluated for the rationality of the compatibility of the prescriptions.[Results] Compared with the model group,the blood flow of uterus in the Shaofu Zhuyu Decoction group,Huoxue group and Wenjing group was significantly decreased,plasma viscosity decreased,hematocrit,erythrocyte aggregation index,electrophoresis index and deformation index were all decreased,PT,TT,APTT was prolonged,FIB decreased,TXA2 decreased,and PGI2 increased.[Conclusion] Shaofu Zhuyu Decoction has a significant therapeutic effect on primary dysmenorrhea rats with cold-coagulating blood stasis syndrome,and the blood-activating component and the warming component have significant synergistic effects. |
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