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| Herb-drug interaction mechanism of Tripterygium glycosides and Furosemide in the treatment of nephrotic syndrome based on network pharmacology |
| Hits 937 Download times 616 Received:May 23, 2020 |
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| DOI
10.11656/j.issn.1672-1519.2020.10.21 |
| Key Words
tripterygium glycosides;furosemide;nephrotic syndrome;network pharmacology;drug-drug interaction |
| Author Name | Affiliation | E-mail | | YUAN Xinhui | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Ziqiang | Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | HUANG Yuhong | Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | WANG Baohe | Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | wbh3423@sina.com | | DU Xi | Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | duxijob@aliyun.com。 |
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| Abstract
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| [Objective] To study the mechanism of the interaction between the main components of tripterygium glycosides (TG) and furosemide in the treatment of nephrotic syndrome (NS) by network pharmacology.[Methods] The main components of TG,the two drug's NS-related human targets were searched in multiple databases. Molecular docking between drugs and targets was performed. Protein-protein interaction (PPI) network maps,target-tissue distribution network maps,compound-target network maps,compound-target-path network maps was mapped,and the similarities and differences and possible interactions between the two drugs was analysed.[Results] There were 14 main components of TG,136 human NS targets of TG and 81 of furosemide. TG covers 70 targets of furosemide. The main tissues shared by the two drugs are liver,bone marrow,whole blood,smooth muscle,lung,whole brain,pons,tonsils,cardiomyocytes,T cells,B cells,and the like. The binding activity of the TG drug to the target is better than furosemide. The two drugs intervene in human apoptosis,platelet activation and other 27 signaling pathways through targeted sites.[Conclusion] TG and furosemide have drug interactions in the treatment of NS,which act on multiple targets of the human body and affect the treatment of diseases by intervening multiple signaling pathways. |
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