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| Analysis of network pharmacology mechanism of Optimized New Shengmai Powder in treating heart failure |
| Hits 1083 Download times 767 Received:May 20, 2020 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2020.10.22 |
| Key Words
Optimized New Shengmai Powder;heart failure;network pharmacology;mechanism analysis |
| Author Name | Affiliation | E-mail | | YAN Haifeng | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | WANG Xianliang | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | WANG Shuai | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | HOU Yazhu | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | YANG Zhihua | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | HU Zhen | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | MAO Jingyuan | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | jymao@126.com。 |
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| Abstract
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| [Objective] To analyze the mechanism of Optimized New Shengmai Powder in treating of chronic heart failure (CHF) by network pharmacology.[Methods] Based on Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP),BATMAN-TCM and UniProt database,the main active components and corresponding targets of Optimized New Shengmai Powder were acquired,using GeneCards database to retrieve CHF related targets,through the analysis of OmicShare website and combining with the software of Cytoscape-v3.6.0,the network diagram of traditional Chinese medicine-potential compounds-potential targets-disease of Optimized New Shengmai Powder was constructed,the Gene function (GO) and Kyoto gene and genome encyclopedia (KEGG) pathways of potential targets were enriched using the DAVID database.[Results] According to Drug-likeness (DL),Oral bioavailability (OB) and Score cutoff,85 potential compounds and 89 targets related to CHF were screened,among them,there were quercetin,luteolin,kaempferol,and the targets included SCN5A,ADRB2,NOS2,etc. Functional enrichment analysis included a total of 497 GO items involving biological processes,molecular functions and cellular components,which were mainly involved in the regulation of apoptosis,proliferation,hypoxia and inflammatory response. 139 KEGG pathways were enriched,which are mainly related to the HIF-1,PI3K-Akt and TNF signaling pathways.[Conclusion] The Optimized New Shengmai Powder for CHF treatment has the function of multiple components,multiple targets and multiple pathways,which provides a reference direction for further study on the potential complex mechanism of Optimized New Shengmai Powder for CHF treatment. |
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