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| Effect of Linggui Zhugan Decoction on gastric motility in patients with chronic heart failure of heart yang deficiency syndrome |
| Hits 1228 Download times 894 Received:June 02, 2020 |
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| DOI
10.11656/j.issn.1672-1519.2020.11.11 |
| Key Words
Linggui Zhugan Decoction;chronic heart failure;mosapride;gastric emptying time |
| Author Name | Affiliation | E-mail | | LI Jie | Department of Cardiology, Tianjin Nankai Hospital, Tianjin 300100, China | | | GAO Lu | Department of Cardiology, Tianjin Nankai Hospital, Tianjin 300100, China | | | ZHANG Hong | Department of Cardiology, Tianjin Nankai Hospital, Tianjin 300100, China | zhanghong620107@126.com |
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| Abstract
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| [Objective] To observe the effect of Linggui Zhugan Decoction on gastric motility in patients with chronic heart failure (CHF) due to heart yang deficiency,and to explore the therapeutic effect of Linggui Zhugan Decoction on gastric motility decline in CHF patients,so as to provide new ideas for clinical treatment.[Methods] Ninety patients who met the standard were randomly divided into control group,Western medicine group and Chinese medicine group,with 30 cases in each group. All three groups were given standardized anti-heart failure treatment,while Western medicine group was given mosapride and Chinese medicine group was given Linggui Zhugan Decoction. The digestive tract symptom score,gastric emptying time,BNP level,left ventricular ejection fraction (EF%) and quality of life score of the three groups were statistically analyzed before treatment,2 weeks after treatment and 4 weeks after treatment.[Results] Two weeks after treatment,compared with the control group,the GSRS score,BNP level,and quality of life scores of the other two groups all decreased,and the gastric emptying time was shortened. The differences in GSRS score,gastric emptying time,and quality of life score were statistically significant (P<0.05);compared with the Western medicine group,the BNP level and quality of life score of the Chinese medicine group decreased more significantly,and the difference was statistically significant (P<0.05). After 4 weeks of treatment,compared with 2 weeks after treatment,the indicators of the three groups of patients all decreased,the difference was statistically significant (P<0.05);compared with the other two groups of patients,the decrease of each index of the patients in the Chinese medicine group was more obvious,and the difference was statistically significant (P<0.05). The EF value of two groups of patients increased after 4 weeks of treatment compared with that before treatment,and the difference of EF value of the patients in the Chinese medicine group before and after treatment was statistically significant (P<0.05).[Conclusion] Linggui Zhugan Decoction can reduce the GSRS score and BNP level of CHF patients with heart yang deficiency syndrome,increase the EF value,shorten the gastric emptying time,improve the quality of life,and the efficacy is better than mosapride. At the same time,with the prolonged treatment time,the curative effect is more obvious. |
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