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| Study on the medication of Guide to Clinical Practice with Medical Record: Lindai based on data mining and network pharmacology |
| Hits 1138 Download times 818 Received:June 20, 2020 |
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| DOI
10.11656/j.issn.1672-1519.2020.11.12 |
| Key Words
data mining;network pharmacology;guide to clinical practice with medical record;YE Tianshi;lindai |
| Author Name | Affiliation | E-mail | | HUANG Ling | Beijing University of Chinese Medicine, Beijing 100029, China | | | JIANG Mei | Beijing University of Chinese Medicine, Beijing 100029, China | 695764439@qq.com |
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| Abstract
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| [Objective] To explore the prescription medication rule in Guide to Clinical Practice with Medical Record:Lindai,explore the main active components of the basic prescription of lindai,and preliminarily study the treatment mechanism of the basic prescription of lindai.[Methods] TCMISS was used to analyze medication rules of prescriptions,explore the core drugs and new prescription. TCMSP,TCM-Mesh,HIT,TCM-ID,HPO,DrugBank,CTD and KEGG were used to analyze interaction relationship and related pathways among the drug targets in the basic prescription of lindai. The correlation were analyzed by STRING.[Results] The 21 prescriptions and 54 drugs were obtained,and 2 core drug combinations and basic prescription of treating lindai were excavated. The 1 192 target genes of basic prescriptions of treating lindai,52 target genes of lindai,10 target genes of drug-disease intersection and 6 related pathways were obtained.[Conclusion] In the early stage of treating lindai,YE Tianshi focuses on coordinating heart and kidney,while in the later stage,it focuses on nourishing liver and kidney. The mechanism of drug action may be immune inflammation,hormone regulation. It was affected by complex multi-targets and multi-pathways related with phagosome and NOD-like receptor signaling pathway. |
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